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Biomedicines
Volume 10
Issue 12
10.3390/biomedicines10123079
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Review
Peer-Review Record

The Functional Properties and Physiological Roles of Signal-Transducing Adaptor Protein-2 in the Pathogenesis of Inflammatory and Immune Disorders

Biomedicines 2022, 10(12), 3079; https://doi.org/10.3390/biomedicines10123079
by Jun-ichi Kashiwakura 1,*, Kenji Oritani 2 and Tadashi Matsuda 3,*
Biomedicines 2022, 10(12), 3079; https://doi.org/10.3390/biomedicines10123079
Submission received: 5 November 2022 / Revised: 24 November 2022 / Accepted: 26 November 2022 / Published: 30 November 2022
(This article belongs to the Special Issue Pathogenesis and Treatment of Autoimmune and Inflammatory Diseases)

Round 1

Reviewer 1 Report

The authors review the functions performed by signal-transducing adapter protein-2 (STAP-2) in health situations and in some diseases. In general, the article is correct and adequately condenses the knowledge about STAP-2.

Comments:

The title is inappropriate. And this for several reasons: 1) The article is not only about new ("Novel") contributions, but it is a review of what is known about STAP-2. 2) Much of the work deals with the physiological functions of STAP-2 and not only pathology. 3) A notable chapter is the role exerted on macrophages (and not just T lymphocytes) and their involvement in the synthesis of proinflammatory cytokines. 4) It also deals with the involvement of the protein in neoplasms.

The bibliography is somewhat outdated and does not include several of the recent articles referring to STAP-2 and its involvement in inflammatory and autoimmune diseases

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript reviews how adaptor protein STAP-2 affects the pathogenesis of T cell-mediated inflammation, autoimmune diseases and cancer, suggesting novel therapeutic strategies by targeting STAP-2.

The work is concise, informative and appropriate for the aim of the study.
Overall, the manuscript needs no revision and can be published in its present form.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The article may be published in its current form. The corrections respond to the aspects raised in the previous review

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