Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Experiments
2.2. Measurement of Dorsal Skin Transept Water Loss and Capacitance
2.3. Preparation and Staining of Dorsal Skin, Kidney, and Liver Samples
2.4. Enzyme-Linked Immunosorbent Assay (ELISA) Analysis
2.5. Western Blotting
2.6. Statistical Analysis
3. Results
3.1. Effect of Aging on Body Weight, Blood Glucose Level, and Skin Condition in KK-Ay/Tajcl Mice
3.2. Effect of Aging on TEWL, Skin Hydration, Skin Thickness, and Mast Cell and Collagen Expression in KK-Ay/TaJcl Mice
3.3. The Expression of Skin Mast Cell and Skin Histamine and Matrixmetalloproteinase-1 Expression in Aging KK-Ay/TaJcl Mice
3.4. Kidney Condition and Weight, and Blood Creatinine and Hyaluronic Acid Levels in Aging KK-Ay/Tajcl Mice
3.5. Aging Effects IL-6, TNF-α and Endostatine Blood Levels and Kidney Angiopoietin 1 and 2 Levels in KK-Ay/Tajcl Mice
3.6. Liver Condition and Weight, and Glutamic Oxaloacetic Transaminase and Glutamic Pyruvic Transaminase Blood Levels in Response to Aging in KK-Ay/Tajcl Mice
3.7. Effect of Aging on Reactive Oxygen Species and Ionized Calcium-Binding Adapter Molecule 1 and CC-Chemokine Receptor 7 Expression in KK-Ay/Tajcl Mice
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Hiramoto, K.; Goto, K.; Tanaka, S.; Horikawa, T.; Ooi, K. Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice. Biomedicines 2022, 10, 2648. https://doi.org/10.3390/biomedicines10102648
Hiramoto K, Goto K, Tanaka S, Horikawa T, Ooi K. Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice. Biomedicines. 2022; 10(10):2648. https://doi.org/10.3390/biomedicines10102648
Chicago/Turabian StyleHiramoto, Keiichi, Kenji Goto, Shota Tanaka, Tsuneki Horikawa, and Kazuya Ooi. 2022. "Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice" Biomedicines 10, no. 10: 2648. https://doi.org/10.3390/biomedicines10102648