Increased Extrasynaptic Glutamate Escape in Stochastically Shaped Probabilistic Synaptic Environment
Abstract
:1. Introduction
1.1. High-Affinity Astroglial Transporters Control Extrasynaptic Actions of Glutamate
1.2. Theoretical Models to Estimate Extrasynaptic Glutamate Escape
1.3. Glutamate Binding by Transporter-Enriched Astroglial Surfaces
2. Methods
2.1. Stochastic Model of Neuropil Geometry
2.2. Interaction between Diffusing Molecules and Simulated Cell Surfaces
3. Results
3.1. Glutamate Release, Diffusion, and Transporter Binding
3.2. Exploring Free Parameters
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Savtchenko, L.P.; Rusakov, D.A. Increased Extrasynaptic Glutamate Escape in Stochastically Shaped Probabilistic Synaptic Environment. Biomedicines 2022, 10, 2406. https://doi.org/10.3390/biomedicines10102406
Savtchenko LP, Rusakov DA. Increased Extrasynaptic Glutamate Escape in Stochastically Shaped Probabilistic Synaptic Environment. Biomedicines. 2022; 10(10):2406. https://doi.org/10.3390/biomedicines10102406
Chicago/Turabian StyleSavtchenko, Leonid P., and Dmitri A. Rusakov. 2022. "Increased Extrasynaptic Glutamate Escape in Stochastically Shaped Probabilistic Synaptic Environment" Biomedicines 10, no. 10: 2406. https://doi.org/10.3390/biomedicines10102406