Rationalization of In-Situ Synthesized Plasmonic Paper for Colorimetric Detection of Glucose in Ocular Fluids
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Department of Optometry, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Korea
2
Convergence Institute of Biomaterials and Bioengineering, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Korea
*
Author to whom correspondence should be addressed.
Chemosensors 2020, 8(3), 81; https://doi.org/10.3390/chemosensors8030081
Received: 15 July 2020
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Revised: 18 August 2020
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Accepted: 27 August 2020
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Published: 1 September 2020
(This article belongs to the Section Optical Chemical Sensors)
Tear glucose is an intriguing biofluid that includes potential biomarkers. While many sensors have emerged nowadays, there is still demand for advanced sensors with nonenzymatic, simple, cost-effective sensing mechanism. Herein, we present a paper-based colorimetric assay by utilizing a gold nanoparticle formation. Experimental characterization substantiated a mechanism in this in situ reduction. Scanning electron microscopy, UV-visible spectrometry, etc. were involved in the scrutiny. As a result, we reached for the rationale whereas the particle formation can be utilized for a glucose sensing using tears. This paper-based detection was insusceptible to physiological tear matrix, i.e., chloride ion effect, false-positive error and synergistic effect by antioxidants. In addition, we evaluated its analytical performance in an artificial tear assay. Of the obtained a linear regressions, the concentration range corresponded to the physiological or pathologic reference range. In addition, within the low-concentration range, a high correlation was resulted 0.965. Furthermore, we investigated statistical validation by employing the Bland–Altman plot. In the end sections of this paper, we denoted its ready-to-use merits by simplicity—as well as the further application of our plasmonic paper.
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Keywords:
gold nanoparticles; nanocomposite; glucose; tear; plasmonic; paper-based
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MDPI and ACS Style
Kim, H.J.; Hyung, J.; Noh, H. Rationalization of In-Situ Synthesized Plasmonic Paper for Colorimetric Detection of Glucose in Ocular Fluids. Chemosensors 2020, 8, 81. https://doi.org/10.3390/chemosensors8030081
AMA Style
Kim HJ, Hyung J, Noh H. Rationalization of In-Situ Synthesized Plasmonic Paper for Colorimetric Detection of Glucose in Ocular Fluids. Chemosensors. 2020; 8(3):81. https://doi.org/10.3390/chemosensors8030081
Chicago/Turabian StyleKim, Hyeok J., Jiwoo Hyung, and Hyeran Noh. 2020. "Rationalization of In-Situ Synthesized Plasmonic Paper for Colorimetric Detection of Glucose in Ocular Fluids" Chemosensors 8, no. 3: 81. https://doi.org/10.3390/chemosensors8030081
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