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Open AccessFeature PaperArticle

Towards Rational Chemosensor Design through Improved Understanding of Experimental Parameter Variation and Tolerance in Cyclodextrin-Promoted Fluorescence Detection

Department of Chemistry, University of Rhode Island, Kingston, RI 02881, USA
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Chemosensors 2017, 5(4), 34; https://doi.org/10.3390/chemosensors5040034
Received: 18 October 2017 / Revised: 1 December 2017 / Accepted: 7 December 2017 / Published: 12 December 2017
(This article belongs to the Special Issue Label-Free Biosensors and Chemical Sensors)
We have previously developed a highly efficient fluorescence-based toxicant-detection method that operates in complex environments to detect aromatic toxicants and toxicant metabolites with high sensitivity and selectivity. This method relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold, and uses a variety of non-covalent interactions between the cyclodextrin, toxicant, and fluorophore to enable efficient detection. Reported herein is an investigation of the effect of various experimental parameters, including host concentration, temperature, pH, salt, and solvent, on the observed energy-transfer efficiencies. These results advance our understanding of γ-cyclodextrin-based association complexes and provide crucial information for the development of fluorescence-based sensors using such complexation and the resultant fluorescence-based detection. View Full-Text
Keywords: cyclodextrin; energy transfer; optical spectroscopy; linear discriminant analysis; fluorescence detection cyclodextrin; energy transfer; optical spectroscopy; linear discriminant analysis; fluorescence detection
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MDPI and ACS Style

DiScenza, D.J.; Culton, E.; Verderame, M.; Lynch, J.; Serio, N.; Levine, M. Towards Rational Chemosensor Design through Improved Understanding of Experimental Parameter Variation and Tolerance in Cyclodextrin-Promoted Fluorescence Detection. Chemosensors 2017, 5, 34.

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