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Chemosensors 2017, 5(1), 6;

Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel

Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China
Authors to whom correspondence should be addressed.
Academic Editor: Manel Del Valle
Received: 15 November 2016 / Revised: 21 January 2017 / Accepted: 25 January 2017 / Published: 7 February 2017
(This article belongs to the Special Issue Bioinspired Chemical Sensing)
Full-Text   |   PDF [2339 KB, uploaded 10 February 2017]   |  


In this study, a novel three-component hydrogel has been designed and fabricated via hierarchical self-assembly by amino acid derivative (NPPD), riboflavin (RF) and α-cyclodextrin (α-CD). These molecules were aggregated to form some fibrous structures based on hydrogen bond and π–π stacking. The results show that the hydrogel has a specific response to α-amylase and the fluorescence disappears once hydrolyzed. Therefore, this multi-component hydrogel has potential application in the field of drug delivery. View Full-Text
Keywords: hydrogel; amylase-response; hydrogen bond; drug delivery hydrogel; amylase-response; hydrogen bond; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Y.; Peng, Y.; Liu, W.; Fan, Y.; Wu, Y.; Li, X.; Fan, X. Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel. Chemosensors 2017, 5, 6.

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