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Article

Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes

1
Department of Physical Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain
2
Department of Chemical Engineering, Physical Chemistry and Materials Science, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, Avda. de las Fuerzas Armadas s/n, 21071 Huelva, Spain
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Centre of Applied Science for Health, Department of Applied Science, Technological University of Dublin, Tal13 laght, D24 FKT9 Dublin, Ireland
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Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Avda. Manuel Siurot s/n, 41013 Seville, Spain
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Clinical Unit of Infectious Diseases and Microbiology, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, 41013 Seville, Spain
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Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Guo-Hui Pan
Chemosensors 2022, 10(7), 281; https://doi.org/10.3390/chemosensors10070281
Received: 10 June 2022 / Revised: 6 July 2022 / Accepted: 11 July 2022 / Published: 14 July 2022
(This article belongs to the Collection Women Special Issue in Chemosensors and Analytical Chemistry)
Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies. A terminally substituted difluorene-diester Schiff Base calix[4]arene has been studied in this work as possible nanovector to be used in gene therapy. Changes to luminescent behavior of the calixarene macrocycle are reported in the presence of ct-DNA. The calixarene macrocycle interacts with calf thymus DNA (ct-DNA), generating changes in its conformation. Partial double-strand denaturation is induced at low concentrations of the calixarene, resulting in compaction of the ct-DNA. However, interaction between calixarene molecules themselves takes place at high calixarene concentrations, favoring the decompaction of the polynucleotide. Based on cytotoxicity studies, the calixarene macrocycle investigated has the potential to be used as a nanovehicle and improve the therapeutic efficacy of pharmacological agents against tumors. View Full-Text
Keywords: calixarenes; ct-DNA; denaturation; compaction; gene therapy; nanocarriers calixarenes; ct-DNA; denaturation; compaction; gene therapy; nanocarriers
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MDPI and ACS Style

Lebrón, J.A.; López-López, M.; Moyá, M.L.; Deasy, M.; Muñoz-Wic, A.; García-Calderón, C.B.; Valle Rosado, I.; López-Cornejo, P.; Bernal, E.; Ostos, F.J. Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes. Chemosensors 2022, 10, 281. https://doi.org/10.3390/chemosensors10070281

AMA Style

Lebrón JA, López-López M, Moyá ML, Deasy M, Muñoz-Wic A, García-Calderón CB, Valle Rosado I, López-Cornejo P, Bernal E, Ostos FJ. Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes. Chemosensors. 2022; 10(7):281. https://doi.org/10.3390/chemosensors10070281

Chicago/Turabian Style

Lebrón, José Antonio, Manuel López-López, María Luisa Moyá, Mary Deasy, Ana Muñoz-Wic, Clara Beatriz García-Calderón, Iván Valle Rosado, Pilar López-Cornejo, Eva Bernal, and Francisco José Ostos. 2022. "Fluorescent Calixarene-Schiff as a Nanovehicle with Biomedical Purposes" Chemosensors 10, no. 7: 281. https://doi.org/10.3390/chemosensors10070281

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