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Article

Diabetes Mellitus—A Risk Factor for Unfavourable Outcome in COVID-19 Patients—The Experience of an Infectious Diseases Regional Hospital

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“Grigore T. Popa”, University of Medicine and Pharmacy Iasi, Discipline of Infectious Diseases, 700116 Iasi, Romania
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“Saint Parascheva”, Infectious Diseases Clinical Universitary Hospital Iasi, 700116 Iasi, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Pierpaolo Di Micco and Anna Annunziata
Healthcare 2021, 9(7), 788; https://doi.org/10.3390/healthcare9070788
Received: 13 May 2021 / Revised: 18 June 2021 / Accepted: 19 June 2021 / Published: 23 June 2021
Early research into the implications concerning the evolution of the infection caused by the new coronavirus in people with glucose metabolism dysfunction, in this case diabetics, shows that severe forms of the disease predominate in this risk category. Moreover, it seems that even in patients with normal glycaemic status, COVID-19 may predispose to the development of hyperglycaemia which modulates immune mechanisms and inflammatory responses, with direct effects on morbidity and mortality. Thus, taking into account these scientific data, as well as the increased frequency of diabetes in the general population, we aimed to assess the risk of an unfavourable outcome of diabetic patients, which is in a strong connection with the presence and severity of pulmonary disease such as interstitial pneumonia/bronchopneumonia, as well as the effectiveness of Tocilizumab administration. The results of our study indicate a three-fold higher risk of death in patients with diabetes and COVID-19 (RR = 3.03; IC95%: 2.37–3.86; p = 0.001),compared to nondiabetic patients, and the risk of developing severe forms of acute respiratory failure was 1.5 times higher in the first studied category. In conclusion, we can say that the diabetic diagnosed with SARS-CoV-2 infection is more predisposed to immunological and organic dysfunctions that may ultimately result in death, and treatment with monoclonal anti-IL-6 antibodies was more effective in diabetic patients than non-diabetics (p < 0.05). The effectiveness of Tocilizumab was significant in both studied groups, but diabetic patients responded better to this therapy compared to non-diabetes-mellitus (DM) ones (76.7% vs. 35% p = 0.001).
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Keywords: cytokine storm; diabetes mellitus; COVID-19 cytokine storm; diabetes mellitus; COVID-19
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MDPI and ACS Style

Miftode, E.; Miftode, L.; Coman, I.; Prepeliuc, C.; Obreja, M.; Stămăteanu, O.; Părângă, T.G.; Leca, D.; Pleşca, C.E. Diabetes Mellitus—A Risk Factor for Unfavourable Outcome in COVID-19 Patients—The Experience of an Infectious Diseases Regional Hospital. Healthcare 2021, 9, 788. https://doi.org/10.3390/healthcare9070788

AMA Style

Miftode E, Miftode L, Coman I, Prepeliuc C, Obreja M, Stămăteanu O, Părângă TG, Leca D, Pleşca CE. Diabetes Mellitus—A Risk Factor for Unfavourable Outcome in COVID-19 Patients—The Experience of an Infectious Diseases Regional Hospital. Healthcare. 2021; 9(7):788. https://doi.org/10.3390/healthcare9070788

Chicago/Turabian Style

Miftode, Egidia, Larisa Miftode, Ioana Coman, Cristian Prepeliuc, Maria Obreja, Oana Stămăteanu, Tudorița G. Părângă, Daniela Leca, and Claudia E. Pleşca. 2021. "Diabetes Mellitus—A Risk Factor for Unfavourable Outcome in COVID-19 Patients—The Experience of an Infectious Diseases Regional Hospital" Healthcare 9, no. 7: 788. https://doi.org/10.3390/healthcare9070788

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