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Article

Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women

1
Institute of Sports Health Science, Sunmoon University, 70, Sunmoon-ro 221 beon-gil, Tangjeong-Myeon, Asan-si 31460, Korea
2
Data Center, Hannam University, 70 Hannamro, Daedeok-Gu, Daejeon 34430, Korea
3
Department of Exercise Prescription, Dongshin University, 185, Geonjae-Ro, Naju, Jeonnam 58245, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Daniela Figueiredo and Oscar Ribeiro
Healthcare 2021, 9(6), 711; https://doi.org/10.3390/healthcare9060711
Received: 19 May 2021 / Revised: 7 June 2021 / Accepted: 8 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue Healthcare and Rehabilitation of Older Adults)
We investigated the effects of a 15-week complex exercise program on osteoarthritis and sarcopenia by analyzing anabolic effects and the impact on the activities of daily living (ADLs). Nineteen women aged ≥60 years with sarcopenia (SEG, n = 9) or diagnosed with osteoarthritis with sarcopenia (OSEG, n = 10) were enrolled and underwent an exercise program. Insulin-like growth factor 1 (IGF-1), irisin, myostatin, interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-a) levels were analyzed pre- and post-intervention. Thigh cross-sectional area (TCSA) was measured pre- and post-intervention via computed tomography. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short Physical Performance Battery (SPBB) were assessed pre- and post-interventions to assess ADL. There was a significant interaction effect between SEG and OSEG at the IGF-1 level post-intervention. Irisin increased and myostatin decreased post-intervention in both groups. IL-10 increased and TNF-α decreased post-intervention with a significant interaction effect in the OSEG group. TCSAs increased post-intervention in both groups. There was a significant interaction between the two groups. OSEG showed a greater WOMAC decrease and SPPB increase post-intervention, and there was a significant interaction effect. Combined exercise may be effective in improving biochemical factors, anabolic effects, and ADL in elderly women with osteoarthritis and sarcopenia. View Full-Text
Keywords: sarcopenia; osteoarthritis; complex exercise; myokine; TCSA sarcopenia; osteoarthritis; complex exercise; myokine; TCSA
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MDPI and ACS Style

Park, J.; Bae, J.; Lee, J. Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women. Healthcare 2021, 9, 711. https://doi.org/10.3390/healthcare9060711

AMA Style

Park J, Bae J, Lee J. Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women. Healthcare. 2021; 9(6):711. https://doi.org/10.3390/healthcare9060711

Chicago/Turabian Style

Park, Jaeyong, Jongjin Bae, and Jungchul Lee. 2021. "Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women" Healthcare 9, no. 6: 711. https://doi.org/10.3390/healthcare9060711

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