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Open AccessReview

Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca2+ Flux Response

1
Research Commission on Mind-Body Therapies, Italian Society of Psycho Neuro Endocrino Immunology, 00198 Rome, Italy
2
Department of Movement, Human and Health Science, University of Rome “Foro Italico”, 00135 Rome, Italy
3
Italian Triathlon Federation, 00135 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Vincenzo Lionetti
Healthcare 2021, 9(2), 181; https://doi.org/10.3390/healthcare9020181
Received: 23 December 2020 / Revised: 26 January 2021 / Accepted: 4 February 2021 / Published: 9 February 2021
The present narrative review aims to highlight the possible effects manual therapies could have on cells and mitochondria, as these effects could improve athletic performance management. To this aim, this review summarizes the relationship between mechanical stimulation, with a special focus on physical activity, and cell response based on the most recent mechanobiology findings. Mechanobiology analyzes how cells respond to mechanical stressors coming from the environment. Indeed, endogenous (e.g., blood pressure, heartbeat and gastrointestinal motility) and exogenous (e.g., physical activity and manual therapies) stimuli can induce biochemical and epigenetic modifications that alter protein synthesis with heavy consequences on cell behavior. Mechanical stress can also influence mitochondrial behavior (i.e., biogenesis, autophagy, fusion, fission and energy production), sarcoplasmic response and calcium ion (Ca2+) flux. Since manual therapies have been shown to affect the extracellular matrix, which represents a primary source of mechanical stress that may alter both the cytoskeleton and mitochondrial metabolism, it is conceivable manual therapies could also affect cellular and mitochondrial behavior. Lastly, by suggesting possible directions for future laboratory and clinical studies, the authors expect this review to inspire further research on how manual therapies could affect bioenergetic metabolism and, thus, athletic performance. View Full-Text
Keywords: mechanotransduction; mitochondria; athletic performance; stress response; manual therapy; calcium ions; bioenergetic metabolism mechanotransduction; mitochondria; athletic performance; stress response; manual therapy; calcium ions; bioenergetic metabolism
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MDPI and ACS Style

Regno, A.; Parisi, A.; Chiera, M.; Barsotti, N.; Cerulli, C.; Grazioli, E.; Tamburri, A.; Bruscolotti, M. Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca2+ Flux Response. Healthcare 2021, 9, 181. https://doi.org/10.3390/healthcare9020181

AMA Style

Regno A, Parisi A, Chiera M, Barsotti N, Cerulli C, Grazioli E, Tamburri A, Bruscolotti M. Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca2+ Flux Response. Healthcare. 2021; 9(2):181. https://doi.org/10.3390/healthcare9020181

Chicago/Turabian Style

Regno, Alex; Parisi, Attilio; Chiera, Marco; Barsotti, Nicola; Cerulli, Claudia; Grazioli, Elisa; Tamburri, Alessandra; Bruscolotti, Marco. 2021. "Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca2+ Flux Response" Healthcare 9, no. 2: 181. https://doi.org/10.3390/healthcare9020181

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