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The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review

Department of Health and Human Performance, Berea College, Berea, KY 40404, USA
Department of Social & Behavioral Health, School of Public Health, University of Nevada, Las Vegas, NV 89119, USA
Office of Research, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, NV 89102, USA
Graduate Department of Public Health, School of Health Sciences, Regis College, Weston, MA 02493, USA
Author to whom correspondence should be addressed.
Academic Editor: Phyo Kyaw Myint
Healthcare 2021, 9(11), 1573;
Received: 18 October 2021 / Revised: 15 November 2021 / Accepted: 17 November 2021 / Published: 18 November 2021
With the aging population, dementia emerges as a public health concern. In 2012, the Health and Retirement Study found that 8.8% of adults over 65 years suffered from dementia. The etiopathogenesis and treatment of dementia are not well understood. Antioxidant properties of Vitamin E and its major elements tocopherols and tocotrienols have been reported to be effective in slowing down the progression of dementia from its initial stage of Mild cognitive impairment (MCI). Therefore, the current review aims to explore the role of vitamin E on MCI. A literature search using the key words “Vitamin E, tocopherols, tocotrienols, and mild cognitive impairment” was conducted in MEDLINE (PubMed), CINAHL, and Google Scholar. The inclusion criteria were: (1) articles published in the past ten years; (2) published in English language; (3) published in peer-reviewed journals; and (4) descriptive and epidemiological or evaluation studies. Articles published prior to 2010, focused on other forms of dementia than MCI, grey literature and non-peer-reviewed articles were excluded. A total of 22 studies were included in the narrative synthesis. The results were equivocal. Eleven studies showed some level of the neuroprotective effect of Vitamin E, tocopherols and tocotrienols on the progression of MCI. The mixed results of this review suggest further exploration of the possible protective effects of Vitamin E on the development of dementia. Future studies can be conducted to decipher antioxidant properties of vitamin E and its association with slowing down the cognitive decline. View Full-Text
Keywords: dementia; mild cognitive impairment; vitamin E; amnesia dementia; mild cognitive impairment; vitamin E; amnesia
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MDPI and ACS Style

Lakhan, R.; Sharma, M.; Batra, K.; Beatty, F.B. The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review. Healthcare 2021, 9, 1573.

AMA Style

Lakhan R, Sharma M, Batra K, Beatty FB. The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review. Healthcare. 2021; 9(11):1573.

Chicago/Turabian Style

Lakhan, Ram, Manoj Sharma, Kavita Batra, and Frazier B. Beatty. 2021. "The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review" Healthcare 9, no. 11: 1573.

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