Next Article in Journal
Development of a Portable Dielectric Biosensor for Rapid Detection of Viscosity Variations and Its In Vitro Evaluations Using Saliva Samples of COPD Patients and Healthy Control
Previous Article in Journal
Co-Infection by Waterborne Enteric Viruses in Children with Gastroenteritis in Nepal
Previous Article in Special Issue
Development and Psychometric Properties of The Delayed Childbearing Questionnaire (DCBQ-55)
Article Menu

Export Article

Open AccessReview
Healthcare 2019, 7(1), 10; https://doi.org/10.3390/healthcare7010010

Acute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug Prescription

1
Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Potosí 4234, C1199AC CABA Buenos Aires, Argentina
2
Pharmacology Division, Internal Medicine Department, Hospital Italiano de Buenos Aires, C1199 ABH Buenos Aires, Argentina
*
Author to whom correspondence should be addressed.
Received: 4 December 2018 / Revised: 6 January 2019 / Accepted: 8 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Feature Papers in Healthcare in 2018)
Full-Text   |   PDF [489 KB, uploaded 14 January 2019]   |  

Abstract

Acute kidney injury (AKI) is a common problem in hospitalized patients that is associated with significant morbid-mortality. The impact of kidney disease on the excretion of drugs eliminated by glomerular filtration and tubular secretion is well established, as well as the requirement for drug dosage adjustment in impaired kidney function patients. However, since impaired kidney function is associated with decreased activity of several hepatic and gastrointestinal drug-metabolizing enzymes and transporters, drugs doses adjustment only based on kidney alteration could be insufficient in AKI. In addition, there are significant pharmacokinetics changes in protein binding, serum amino acid levels, liver, kidney, and intestinal metabolism in AKI, thus the determination of plasma drug concentrations is a very useful tool for monitoring and dose adjustment in AKI patients. In conclusion, there are many pharmacokinetics changes that should be taken into account in order to perform appropriate drug prescriptions in AKI patients. View Full-Text
Keywords: pharmacokinetics; acute kidney injury; drug prescription pharmacokinetics; acute kidney injury; drug prescription
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Blanco, V.E.; Hernandorena, C.V.; Scibona, P.; Belloso, W.; Musso, C.G. Acute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug Prescription. Healthcare 2019, 7, 10.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Healthcare EISSN 2227-9032 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top