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Healthcare 2019, 7(1), 10;

Acute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug Prescription

Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Potosí 4234, C1199AC CABA Buenos Aires, Argentina
Pharmacology Division, Internal Medicine Department, Hospital Italiano de Buenos Aires, C1199 ABH Buenos Aires, Argentina
Author to whom correspondence should be addressed.
Received: 4 December 2018 / Revised: 6 January 2019 / Accepted: 8 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Feature Papers in Healthcare in 2018)
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Acute kidney injury (AKI) is a common problem in hospitalized patients that is associated with significant morbid-mortality. The impact of kidney disease on the excretion of drugs eliminated by glomerular filtration and tubular secretion is well established, as well as the requirement for drug dosage adjustment in impaired kidney function patients. However, since impaired kidney function is associated with decreased activity of several hepatic and gastrointestinal drug-metabolizing enzymes and transporters, drugs doses adjustment only based on kidney alteration could be insufficient in AKI. In addition, there are significant pharmacokinetics changes in protein binding, serum amino acid levels, liver, kidney, and intestinal metabolism in AKI, thus the determination of plasma drug concentrations is a very useful tool for monitoring and dose adjustment in AKI patients. In conclusion, there are many pharmacokinetics changes that should be taken into account in order to perform appropriate drug prescriptions in AKI patients. View Full-Text
Keywords: pharmacokinetics; acute kidney injury; drug prescription pharmacokinetics; acute kidney injury; drug prescription

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Blanco, V.E.; Hernandorena, C.V.; Scibona, P.; Belloso, W.; Musso, C.G. Acute Kidney Injury Pharmacokinetic Changes and Its Impact on Drug Prescription. Healthcare 2019, 7, 10.

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