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Article

Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy

1
Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, Solnavägen 9, 171 65 Solna, Sweden
2
Armauer Hansen Research Institute, P.O. Box 1005, Addis Ababa, Ethiopia
3
Department of Microbial, Cellular and Molecular Biology, PO Box 1176, Addis Ababa University, Addis Ababa, Ethiopia
*
Author to whom correspondence should be addressed.
These authors contributed equally to the research.
Proteomes 2020, 8(3), 24; https://doi.org/10.3390/proteomes8030024
Received: 3 August 2020 / Revised: 2 September 2020 / Accepted: 3 September 2020 / Published: 7 September 2020
Treatment of HIV-1-infected patients results in improved clinical and immunological conditions, but severe non-AIDS-related conditions still persist. Novel proteomic platforms have identified inflammatory proteins where abundance is dysregulated in adult treated patients, whereas limited data are available in treated HIV-1 infection of children. Using a proteomic plasma profiling approach comprising 92 inflammation-related molecules, we analyzed specimens from 43 vertically HIV-1-infected children receiving antiretroviral treatment (ART) and matched controls in Ethiopia. The infected children were analyzed as a group and separately, according to age of treatment initiation. Proteins displaying a significantly different abundance between groups were hierarchically clustered and presented in heat maps. Random forest analysis was performed to pin-point proteins discriminating between groups; five proteins (STAMBP, CD5, TFG-α, TRANCE, AXIN1) were the strongest prediction factors for treated HIV-1 infection. TRANCE was previously linked to reduced bone mass levels in HIV-1-infected children. CCL4 chemokine, ligand to HIV-1 co-receptor CCR5, was the most critical protein for successful classification between children who initiated ART at different time points. Our data provide evidence that a dysregulated expression of proteins linked to immunological abnormalities and bone metabolism can be found in HIV-1-infected children with prolonged exposure to ART. View Full-Text
Keywords: inflammation; protein; profiling; plasma; HIV-1; ART; comorbidities; osteopathology; children inflammation; protein; profiling; plasma; HIV-1; ART; comorbidities; osteopathology; children
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MDPI and ACS Style

Lemma, M.; Petkov, S.; Bekele, Y.; Petros, B.; Howe, R.; Chiodi, F. Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy. Proteomes 2020, 8, 24. https://doi.org/10.3390/proteomes8030024

AMA Style

Lemma M, Petkov S, Bekele Y, Petros B, Howe R, Chiodi F. Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy. Proteomes. 2020; 8(3):24. https://doi.org/10.3390/proteomes8030024

Chicago/Turabian Style

Lemma, Mahlet, Stefan Petkov, Yonas Bekele, Beyene Petros, Rawleigh Howe, and Francesca Chiodi. 2020. "Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy" Proteomes 8, no. 3: 24. https://doi.org/10.3390/proteomes8030024

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