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Different Types of Cellular Stress Affect the Proteome Composition of Small Extracellular Vesicles: A Mini Review

Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute—Oncology Center, Gliwice Branch, 44-101 Gliwice, Poland
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Proteomes 2019, 7(2), 23; https://doi.org/10.3390/proteomes7020023
Received: 14 April 2019 / Revised: 14 May 2019 / Accepted: 19 May 2019 / Published: 23 May 2019
(This article belongs to the Special Issue Proteomes of Extracellular Vesicles)
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Abstract

Extracellular vesicles (EVs) are well-known mediators of the cellular response to different stress factors, yet the exact mechanism of their action remains unclear. Hence, the characterization of their cargo, consisting of proteins, nucleic acids, and different classes of metabolites, helps to elucidate an understanding of their function in stress-related communication. The unexpected diversity and complexity of these vesicles requires the incorporation of multiple technologically advanced approaches in EV-oriented studies. This mini review focuses on the invaluable role of proteomics, especially mass spectrometry-based tools, in the investigation of the role of small EVs in their response to stress. Though relatively few experimental works address this issue to date, the available data indicate that stress conditions would affect the composition of protein cargo of vesicles released by stressed cells, as evidenced by the functional importance of such changes in the context of the response of recipient cells. View Full-Text
Keywords: exosome; extracellular vesicles; genotoxic stress; heat shock; hypoxia; mass spectrometry; oxidative stress; proteome exosome; extracellular vesicles; genotoxic stress; heat shock; hypoxia; mass spectrometry; oxidative stress; proteome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Abramowicz, A.; Widłak, P.; Pietrowska, M. Different Types of Cellular Stress Affect the Proteome Composition of Small Extracellular Vesicles: A Mini Review. Proteomes 2019, 7, 23.

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