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Molecular and Physiological Study of Candida albicans by Quantitative Proteome Analysis

1
General Education Center, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe, Hyogo 650-8530, Japan
2
Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
*
Author to whom correspondence should be addressed.
Proteomes 2018, 6(3), 34; https://doi.org/10.3390/proteomes6030034
Received: 26 July 2018 / Revised: 28 August 2018 / Accepted: 11 September 2018 / Published: 18 September 2018
Candida albicans is one of the major pathogens that cause the serious infectious condition known as candidiasis. C. albicans was investigated by proteome analysis to systematically examine its virulence factors and to promote the development of novel pharmaceuticals against candidiasis. Here, we review quantitative time-course proteomics data related to C. albicans adaptation to fetal bovine serum, which were obtained using a nano-liquid chromatography/tandem mass spectrometry system equipped with a long monolithic silica capillary column. It was revealed that C. albicans induced proteins involved in iron acquisition, detoxification of oxidative species, energy production, and pleiotropic stress tolerance. Native interactions of C. albicans with macrophages were also investigated with the same proteome-analysis system. Simultaneous analysis of C. albicans and macrophages without isolating individual living cells revealed an attractive strategy for studying the survival of C. albicans. Although those data were obtained by performing proteome analyses, the molecular physiology of C. albicans is discussed and trials related to pharmaceutical applications are also examined. View Full-Text
Keywords: Candida albicans; macrophage; monolithic silica capillary column; vaccine; virulence Candida albicans; macrophage; monolithic silica capillary column; vaccine; virulence
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Shibasaki, S.; Karasaki, M.; Aoki, W.; Ueda, M. Molecular and Physiological Study of Candida albicans by Quantitative Proteome Analysis. Proteomes 2018, 6, 34.

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