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Advances of Salivary Proteomics in Oral Squamous Cell Carcinoma (OSCC) Detection: An Update

Department of Oral Pathology, College of Dentistry, Baqai University, Super Highway, P.O. Box: 2407, Karachi 74600, Pakistan
Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia
Department of Oral Pathology, Dow Dental College, Dow University of Heath Sciences (DUHS), Baba-E-Urdu Road, Karachi 74200, Pakistan
National Center for Proteomics, University of Karachi, University Road, Karachi 75270, Pakistan
Author to whom correspondence should be addressed.
Academic Editors: Karl-Friedrich Becker and Jacek R. Wisniewski
Proteomes 2016, 4(4), 41;
Received: 11 October 2016 / Revised: 28 November 2016 / Accepted: 6 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Cancer Proteomics)
PDF [1736 KB, uploaded 15 December 2016]


Oral cancer refers to malignancies that have higher morbidity and mortality rates due to the late stage diagnosis and no early detection of a reliable diagnostic marker, while oral squamous cell carcinoma (OSCC) is amongst the world’s top ten most common cancers. Diagnosis of cancer requires highly sensitive and specific diagnostic tools which can support untraceable hidden sites of OSCC, yet to be unleashed, for which plenty of biomarkers are identified; the most recommended biomarker detection medium for OSCC includes biological fluids, such as blood and saliva. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being a non-invasive technique to follow, by analysing the malignant cells’ molecular pathology obtained from saliva through proteomic, genomic and transcriptomic approaches. However, protein biomarkers provide an immense potential for developing novel marker-based assays for oral cancer, hence this current review offers an overall focus on the discovery of a panel of candidates as salivary protein biomarkers, as well as the proteomic tools used for their identification and their significance in early oral cancer detection. View Full-Text
Keywords: saliva; biomarkers; oral squamous cell carcinoma; diagnosis saliva; biomarkers; oral squamous cell carcinoma; diagnosis

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Sannam Khan, R.; Khurshid, Z.; Akhbar, S.; Faraz Moin, S. Advances of Salivary Proteomics in Oral Squamous Cell Carcinoma (OSCC) Detection: An Update. Proteomes 2016, 4, 41.

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