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Review

Impact of Propofol Sedation upon Caloric Overfeeding and Protein Inadequacy in Critically Ill Patients Receiving Nutrition Support

1
College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
2
College of Pharmacy, Union University, Jackson, TN 38305, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Stéphane G. Honoré and Nilesh Patel
Pharmacy 2021, 9(3), 121; https://doi.org/10.3390/pharmacy9030121
Received: 7 May 2021 / Revised: 16 June 2021 / Accepted: 25 June 2021 / Published: 1 July 2021
(This article belongs to the Section Pharmacy Practice and Practice-Based Research)
Propofol, a commonly used sedative in the intensive care unit, is formulated in a 10% lipid emulsion that contributes 1.1 kcals per mL. As a result, propofol can significantly contribute to caloric intake and can potentially result in complications of overfeeding for patients who receive concurrent enteral or parenteral nutrition therapy. In order to avoid potential overfeeding, some clinicians have empirically decreased the infusion rate of the nutrition therapy, which also may have detrimental effects since protein intake may be inadequate. The purpose of this review is to examine the current literature regarding these issues and provide some practical suggestions on how to restrict caloric intake to avoid overfeeding and simultaneously enhance protein intake for patients who receive either parenteral or enteral nutrition for those patients receiving concurrent propofol therapy. View Full-Text
Keywords: propofol; enteral nutrition; parenteral nutrition; fat emulsions; critical illness; nutritional requirements; hypnotics and sedatives; food–drug interactions propofol; enteral nutrition; parenteral nutrition; fat emulsions; critical illness; nutritional requirements; hypnotics and sedatives; food–drug interactions
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MDPI and ACS Style

Dickerson, R.N.; Buckley, C.T. Impact of Propofol Sedation upon Caloric Overfeeding and Protein Inadequacy in Critically Ill Patients Receiving Nutrition Support. Pharmacy 2021, 9, 121. https://doi.org/10.3390/pharmacy9030121

AMA Style

Dickerson RN, Buckley CT. Impact of Propofol Sedation upon Caloric Overfeeding and Protein Inadequacy in Critically Ill Patients Receiving Nutrition Support. Pharmacy. 2021; 9(3):121. https://doi.org/10.3390/pharmacy9030121

Chicago/Turabian Style

Dickerson, Roland N., and Christopher T. Buckley. 2021. "Impact of Propofol Sedation upon Caloric Overfeeding and Protein Inadequacy in Critically Ill Patients Receiving Nutrition Support" Pharmacy 9, no. 3: 121. https://doi.org/10.3390/pharmacy9030121

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