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Article

Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential

1
Laboratory of Toxicology, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia-DF 70910-900, Brazil
2
Department of Botany, Institute of Biology, University of Brasilia, Brasilia-DF 70910-900, Brazil
3
Faculty of Ceilândia, University of Brasilia, Brasilia-DF 72220-275, Brazil
4
Department of Phytotechnology, Federal University of Roraima, Boa Vista-Roraima 69310-000, Brazil
5
Centro Espírita Beneficente União do Vegetal (UDV), Brasília-DF 70040-904, Brazil
*
Author to whom correspondence should be addressed.
Plants 2020, 9(7), 870; https://doi.org/10.3390/plants9070870
Received: 29 May 2020 / Revised: 19 June 2020 / Accepted: 20 June 2020 / Published: 9 July 2020
(This article belongs to the Collection Bioactive Compounds in Plants)
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors β-carbolines, and Psichotria virids, which contains the serotonin receptor agonist N,N dimethyltryptamine (DMT). The objectives of this study were to investigate the chemical profile of B. caapi and of ayahuasca collected in various Brazilian regions. In total, 176 plant lianas, of which 159 B. caapi and 33 ayahuasca samples were analyzed. Dried liana samples were powdered, extracted with methanol, diluted, and analyzed by LC-MS/MS. Ayahuasca samples were diluted and analyzed. Mean concentrations in B. caapi were 4.79 mg/g harmine, 0.451 mg/g harmaline, and 2.18 mg/g tetrahydroharmine (THH), with a high variability among the samples (RSD from 78.9 to 170%). Native B. caapi samples showed significantly higher harmine concentrations than cultivated ones, and samples from the Federal District/Goiás had higher THH content than those collected in the State of Acre. The other Malpighiaceae samples did not contain β-carbolines, except for one D. pubipetala sample. Concentrations in ayahuasca samples ranged from 0.109 to 7.11 mg/mL harmine, 0.012 to 0.945 mg/mL harmaline, 0.09 to 3.05 mg/mL THH, and 0.10 to 3.12 mg/mL DMT. The analysis of paired ayahuasca/B. caapi confirmed that harmine is reduced to harmaline and to THH during the brew preparation. This is the largest study conducted with Malpighiaceae samples and showed a large variability in the main β-carbolines present in B. caapi. This biodiversity is a challenge for standardization of the material used in ethnopharmacological studies of B. caapi and ayahuasca. View Full-Text
Keywords: ß-carbolines; DMT; Banisteriopsis caapi; ayahuasca; Brazil ß-carbolines; DMT; Banisteriopsis caapi; ayahuasca; Brazil
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MDPI and ACS Style

Santos, B.W.L.; Oliveira, R.C.d.; Sonsin-Oliveira, J.; Fagg, C.W.; Barbosa, J.B.F.; Caldas, E.D. Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential. Plants 2020, 9, 870. https://doi.org/10.3390/plants9070870

AMA Style

Santos BWL, Oliveira RCd, Sonsin-Oliveira J, Fagg CW, Barbosa JBF, Caldas ED. Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential. Plants. 2020; 9(7):870. https://doi.org/10.3390/plants9070870

Chicago/Turabian Style

Santos, Beatriz W.L., Regina C.d. Oliveira, Julia Sonsin-Oliveira, Christopher W. Fagg, José B.F. Barbosa, and Eloisa D. Caldas 2020. "Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential" Plants 9, no. 7: 870. https://doi.org/10.3390/plants9070870

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