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Review

Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential

by
Pottathil Shinu
1,*,
Girdhari Lal Gupta
2,*,
Manu Sharma
3,
Shahzad Khan
1,
Manoj Goyal
4,
Anroop B. Nair
5,
Manish Kumar
6,
Wafaa E. Soliman
1,7,
Aminur Rahman
1,
Mahesh Attimarad
5,
Katharigatta N. Venugopala
5,8 and
Abdullah Abdulhamid Ahmed Altaweel
5
1
Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
2
Department of Pharmacology, School of Pharmacy and Technology Management, SVKM’s NMIMS University, Shirpur 425405, India
3
Department of Chemistry, National Forensic Sciences University Delhi Campus, New Delhi 110085, India
4
Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Jubail 35816, Saudi Arabia
5
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
6
Department of Pharmaceutics, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Ambala 133201, India
7
Department of Microbiology and Immunology, Faculty of Pharmacy, Delta University for Science and Technology, Mansoura 11152, Egypt
8
Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4000, South Africa
*
Authors to whom correspondence should be addressed.
Plants 2023, 12(5), 1086; https://doi.org/10.3390/plants12051086
Submission received: 29 January 2023 / Revised: 16 February 2023 / Accepted: 22 February 2023 / Published: 1 March 2023
(This article belongs to the Special Issue Plant Derivatives and Their Pharmaceutical Potential)
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Abstract

Glycyrrhiza glabra L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy in treating several ailments. Natural herbal substances with strong biological activity have recently received much attention. The main metabolite of glycyrrhizic acid is 18β-glycyrrhetinic acid (18βGA), a pentacyclic triterpene. A major active plant component derived from licorice root, 18βGA has sparked a lot of attention due to its pharmacological properties. The current review thoroughly examines the literature on 18βGA, a major active plant component obtained from Glycyrrhiza glabra L. The current work provides insight into the pharmacological activities of 18βGA and the potential mechanisms of action involved. The plant contains a variety of phytoconstituents such as 18βGA, which has a variety of biological effects including antiasthmatic, hepatoprotective, anticancer, nephroprotective, antidiabetic, antileishmanial, antiviral, antibacterial, antipsoriasis, antiosteoporosis, antiepileptic, antiarrhythmic, and anti-inflammatory, and is also useful in the management of pulmonary arterial hypertension, antipsychotic-induced hyperprolactinemia, and cerebral ischemia. This review examines research on the pharmacological characteristics of 18βGA throughout recent decades to demonstrate its therapeutic potential and any gaps that may exist, presenting possibilities for future drug research and development.
Keywords: 18β-glycyrrhetinic acid; licorice; pharmacological action; triterpenoid 18β-glycyrrhetinic acid; licorice; pharmacological action; triterpenoid
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MDPI and ACS Style

Shinu, P.; Gupta, G.L.; Sharma, M.; Khan, S.; Goyal, M.; Nair, A.B.; Kumar, M.; Soliman, W.E.; Rahman, A.; Attimarad, M.; et al. Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential. Plants 2023, 12, 1086. https://doi.org/10.3390/plants12051086

AMA Style

Shinu P, Gupta GL, Sharma M, Khan S, Goyal M, Nair AB, Kumar M, Soliman WE, Rahman A, Attimarad M, et al. Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential. Plants. 2023; 12(5):1086. https://doi.org/10.3390/plants12051086

Chicago/Turabian Style

Shinu, Pottathil, Girdhari Lal Gupta, Manu Sharma, Shahzad Khan, Manoj Goyal, Anroop B. Nair, Manish Kumar, Wafaa E. Soliman, Aminur Rahman, Mahesh Attimarad, and et al. 2023. "Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential" Plants 12, no. 5: 1086. https://doi.org/10.3390/plants12051086

APA Style

Shinu, P., Gupta, G. L., Sharma, M., Khan, S., Goyal, M., Nair, A. B., Kumar, M., Soliman, W. E., Rahman, A., Attimarad, M., Venugopala, K. N., & Altaweel, A. A. A. (2023). Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential. Plants, 12(5), 1086. https://doi.org/10.3390/plants12051086

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