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Article

Not Only a Weed Plant—Biological Activities of Essential Oil and Hydrosol of Dittrichia viscosa (L.) Greuter

1
Department of Biology, Faculty of Science, University of Split, R. Boškovića 33, 21000 Split, Croatia
2
Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, R. Boškovića 33, 21000 Split, Croatia
3
Department of Chemistry, Faculty of Science, University of Split, R. Boškovića 33, 21000 Split, Croatia
*
Author to whom correspondence should be addressed.
Academic Editors: Cecilia Cagliero, Barbara Sgorbini and Patrizia Rubiolo
Plants 2021, 10(9), 1837; https://doi.org/10.3390/plants10091837
Received: 23 July 2021 / Revised: 31 August 2021 / Accepted: 2 September 2021 / Published: 4 September 2021
(This article belongs to the Special Issue Plant Volatiles: A Goldmine Not Fully Explored)
With the increasing interest in obtaining biologically active compounds from natural sources, Dittrichia viscosa (L.) Greuter (Asteraceae) came into our focus as a readily available and aromatic wild shrub widely distributed in the Mediterranean region. This work provides a phytochemical profile of D. viscosa in terms of parallel chemical composition in the lipophilic fraction (essential oil) and the water fraction (hydrosol). GC-MS analysis identified 1,8-cineole, caryophyllene oxide, α-terpenyl acetate, and α-muurolol as the major components of the essential oil, while in the hydrosol p-menth-1-en-9-ol, 1,8-cineole, linalool, cis-sabinene hydrate, and α-muurolol were the major volatile components. 3,4-Dihydroxybenzoic acid was found to be the predominant compound in the hydrosol composition by HPLC analysis. The antimicrobial potential of both extracts was evaluated against thirteen opportunistic pathogens associated with common skin and wound infections and emerging food spoilage microorganisms. The antimicrobial activity of the essential oil suggests that the volatiles of D. viscosa could be used as novel antimicrobial agents. The antiproliferative results of D. viscosa volatiles are also new findings, which showed promising activity against three cancer cell lines: HeLa (cervical cancer cell line), HCT116 (human colon cancer cell line), and U2OS (human osteosarcoma cell line). The decrease in GSH level observed in hydrosol-treated HeLa cells suggests oxidative stress as a possible mechanism of the antiproliferative effect of hydrosol on tumor cells. The presented results are also the first report of significant antiphytoviral activity of hydrosol against tobacco mosaic virus (TMV) infection. Based on the results, D. viscosa might have the potential to be used in crop protection, as a natural disinfectant and natural anticancer agent. View Full-Text
Keywords: Dittrichia viscosa; essential oil; hydrosol; GSH; antimicrobial; antiproliferative; antiphytoviral activity Dittrichia viscosa; essential oil; hydrosol; GSH; antimicrobial; antiproliferative; antiphytoviral activity
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MDPI and ACS Style

Vuko, E.; Dunkić, V.; Maravić, A.; Ruščić, M.; Nazlić, M.; Radan, M.; Ljubenkov, I.; Soldo, B.; Fredotović, Ž. Not Only a Weed Plant—Biological Activities of Essential Oil and Hydrosol of Dittrichia viscosa (L.) Greuter. Plants 2021, 10, 1837. https://doi.org/10.3390/plants10091837

AMA Style

Vuko E, Dunkić V, Maravić A, Ruščić M, Nazlić M, Radan M, Ljubenkov I, Soldo B, Fredotović Ž. Not Only a Weed Plant—Biological Activities of Essential Oil and Hydrosol of Dittrichia viscosa (L.) Greuter. Plants. 2021; 10(9):1837. https://doi.org/10.3390/plants10091837

Chicago/Turabian Style

Vuko, Elma, Valerija Dunkić, Ana Maravić, Mirko Ruščić, Marija Nazlić, Mila Radan, Ivica Ljubenkov, Barbara Soldo, and Željana Fredotović. 2021. "Not Only a Weed Plant—Biological Activities of Essential Oil and Hydrosol of Dittrichia viscosa (L.) Greuter" Plants 10, no. 9: 1837. https://doi.org/10.3390/plants10091837

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