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Article

Variation of Triterpenic Acids in 12 Wild Syzygium formosum and Anti-Inflammation Activity on Human Keratinocyte HaCaT

1
CARBOEXPERT Inc., Daejeon 34134, Korea
2
Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 35015, Korea
3
Translational Immunology Institute, Chungnam National University, Daejeon 35015, Korea
4
Department of Food Science and Nutrition, Chungnam National University, Daejeon 34134, Korea
5
Biotechnology Faculty, Binh Duong University, Thu Dau Mot 820000, Vietnam
6
Department of Food Science and Technology, Chungnam National University, Daejeon 34134, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Cinzia Sanna
Plants 2021, 10(11), 2428; https://doi.org/10.3390/plants10112428
Received: 6 October 2021 / Revised: 4 November 2021 / Accepted: 8 November 2021 / Published: 10 November 2021
Syzygium formosum (Wall.) Masam leaf is known as a Vietnamese traditional herbal medicine used to treat atopic dermatitis and stomach ulcers. Recently, its potent anti-allergic effects were reported with possible active compounds analysis. Here, we collected S. formosum leaves from 12 wild trees and compared compositions of triterpenic acids (TA) with Centella asiatica. Anti-inflammatory activities of S. formosum leaf extract (SFLE) was compared with C. asiatica extract (CAE) using human keratinocyte, HaCaT. In this study, up to seven TAs were identified in SFLE, while only madecassic and asiatic acids were detected in the CAE. Total TA content varied among SFLE, but asiatic, corosolic, and betulinic acids were the major components. Surprisingly, wild tree sample 12 (S12) contained total TA of 27.2 mg/g dry-leaves that was 5-fold greater than that in the C. asiatica sample, and S4 had the highest content of asiatic acid (12.6 mg/g dry-leaves) that accounted for 50% of the total TA. S4 and S12 showed more than 3-fold higher anti-oxidative power than the CAE. In the UVB irradiation model, S4 and S12 (5 μg/mL) strongly repressed mRNA levels of pro-inflammatory cytokines (IL-1β, IL-6, and IL-8) and COX-2, while the CAE at the same condition showed moderate or weak repression. The difference in anti-inflammation effects between the SFLE and the CAE was also confirmed by protein quantifications. Taken together, SFLE has great potentials as a new cosmeceutical ingredient with a higher amount of skin-active phytochemicals. View Full-Text
Keywords: anti-inflammation; secondary metabolite; skin cell; Syzygium formosum; triterpenic acid anti-inflammation; secondary metabolite; skin cell; Syzygium formosum; triterpenic acid
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MDPI and ACS Style

Park, H.-a.; Kim, M.Y.; Lee, N.-Y.; Lim, J.; Park, K.-b.; Lee, C.-K.; Nguyen, V.D.; Kim, J.; Park, J.-T.; Park, J.-I. Variation of Triterpenic Acids in 12 Wild Syzygium formosum and Anti-Inflammation Activity on Human Keratinocyte HaCaT. Plants 2021, 10, 2428. https://doi.org/10.3390/plants10112428

AMA Style

Park H-a, Kim MY, Lee N-Y, Lim J, Park K-b, Lee C-K, Nguyen VD, Kim J, Park J-T, Park J-I. Variation of Triterpenic Acids in 12 Wild Syzygium formosum and Anti-Inflammation Activity on Human Keratinocyte HaCaT. Plants. 2021; 10(11):2428. https://doi.org/10.3390/plants10112428

Chicago/Turabian Style

Park, Hyun-ah, Mi Y. Kim, Nan-Young Lee, Jaeyoon Lim, Kyu-been Park, Chang-Kyu Lee, Van D. Nguyen, Jaehan Kim, Jong-Tae Park, and Jong-Il Park. 2021. "Variation of Triterpenic Acids in 12 Wild Syzygium formosum and Anti-Inflammation Activity on Human Keratinocyte HaCaT" Plants 10, no. 11: 2428. https://doi.org/10.3390/plants10112428

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