Next Article in Journal
Transcriptomic Analysis Reveals Candidate Genes Responding Maize Gray Leaf Spot Caused by Cercospora zeina
Next Article in Special Issue
Proteomic Profile of Glyphosate-Resistant Soybean under Combined Herbicide and Drought Stress Conditions
Previous Article in Journal
Different Growth and Sporulation Responses to Temperature Gradient among Obligate Apomictic Strains of Ulva prolifera
Review

The Generic Risks and the Potential of SDN-1 Applications in Crop Plants

Fachstelle Gentechnik und Umwelt, Frohschammerstr. 14, 80807 Munich, Germany
Academic Editors: Zhengqiang Ma, Michael Eckerstorfer and Sarah Z. Agapito-Tenfen
Plants 2021, 10(11), 2259; https://doi.org/10.3390/plants10112259
Received: 17 August 2021 / Revised: 1 October 2021 / Accepted: 18 October 2021 / Published: 22 October 2021
(This article belongs to the Special Issue Potential Unintended Effects of Genetic Technologies in Plants)
The use of site-directed nucleases (SDNs) in crop plants to alter market-oriented traits is expanding rapidly. At the same time, there is an on-going debate around the safety and regulation of crops altered with the site-directed nuclease 1 (SDN-1) technology. SDN-1 applications can be used to induce a variety of genetic alterations ranging from fairly ‘simple’ genetic alterations to complex changes in plant genomes using, for example, multiplexing approaches. The resulting plants can contain modified alleles and associated traits, which are either known or unknown in conventionally bred plants. The European Commission recently published a study on new genomic techniques suggesting an adaption of the current GMO legislation by emphasizing that targeted mutagenesis techniques can produce genomic alterations that can also be obtained by natural mutations or conventional breeding techniques. This review highlights the need for a case-specific risk assessment of crop plants derived from SDN-1 applications considering both the characteristics of the product and the process to ensure a high level of protection of human and animal health and the environment. The published literature on so-called market-oriented traits in crop plants altered with SDN-1 applications is analyzed here to determine the types of SDN-1 application in plants, and to reflect upon the complexity and the naturalness of such products. Furthermore, it demonstrates the potential of SDN-1 applications to induce complex alterations in plant genomes that are relevant to generic SDN-associated risks. In summary, it was found that nearly half of plants with so-called market-oriented traits contain complex genomic alterations induced by SDN-1 applications, which may also pose new types of risks. It further underscores the need for data on both the process and the end-product for a case-by-case risk assessment of plants derived from SDN-1 applications. View Full-Text
Keywords: genome editing; CRISPR/Cas; site-directed nuclease; SDN-1; risk assessment genome editing; CRISPR/Cas; site-directed nuclease; SDN-1; risk assessment
Show Figures

Figure 1

MDPI and ACS Style

Kawall, K. The Generic Risks and the Potential of SDN-1 Applications in Crop Plants. Plants 2021, 10, 2259. https://doi.org/10.3390/plants10112259

AMA Style

Kawall K. The Generic Risks and the Potential of SDN-1 Applications in Crop Plants. Plants. 2021; 10(11):2259. https://doi.org/10.3390/plants10112259

Chicago/Turabian Style

Kawall, Katharina. 2021. "The Generic Risks and the Potential of SDN-1 Applications in Crop Plants" Plants 10, no. 11: 2259. https://doi.org/10.3390/plants10112259

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop