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Review

The Genus Curcuma and Inflammation: Overview of the Pharmacological Perspectives

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Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh
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Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh
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Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1100, Bangladesh
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Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
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Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
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Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka 1230, Bangladesh
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Pratyasha Health Biomedical Research Center, Dhaka 1230, Bangladesh
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Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo–Ourense Campus, E32004 Ourense, Spain
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Authors to whom correspondence should be addressed.
Plants 2021, 10(1), 63; https://doi.org/10.3390/plants10010063
Received: 15 November 2020 / Revised: 20 December 2020 / Accepted: 25 December 2020 / Published: 30 December 2020
The Curcuma genus has been extensively used for therapeutic purposes in traditional or folk medicine worldwide, including for its anti-inflammatory activity. Curcuma spp.’s active constituents, such as alkaloids, flavonoids, and terpenoids, can act on various targets in the signaling pathway, restrain pro-inflammatory enzymes, lower the production of inflammatory cytokines and chemokines, and reduce oxidative stress, which subsequently suppresses inflammatory processes. Preclinical and clinical studies have reported the predominant anti-inflammatory activity of several Curcuma species. This review provides an overview of the anti-inflammatory effects of different extracts, preparations, and bioactive components in this genus. This analysis may provide a scientific basis for developing new and alternative methods for the isolation of a single entity from this genus to attenuate inflammatory conditions. The Curcuma genus is waiting for researchers interested in developing safe and efficient anti-inflammatory agents for further investigation. View Full-Text
Keywords: Curcuma; inflammation; pro-inflammatory cytokines; anti-inflammatory agents; pharmacology Curcuma; inflammation; pro-inflammatory cytokines; anti-inflammatory agents; pharmacology
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MDPI and ACS Style

Rahaman, M.M.; Rakib, A.; Mitra, S.; Tareq, A.M.; Emran, T.B.; Shahid-Ud-Daula, A.F.M.; Amin, M.N.; Simal-Gandara, J. The Genus Curcuma and Inflammation: Overview of the Pharmacological Perspectives. Plants 2021, 10, 63. https://doi.org/10.3390/plants10010063

AMA Style

Rahaman MM, Rakib A, Mitra S, Tareq AM, Emran TB, Shahid-Ud-Daula AFM, Amin MN, Simal-Gandara J. The Genus Curcuma and Inflammation: Overview of the Pharmacological Perspectives. Plants. 2021; 10(1):63. https://doi.org/10.3390/plants10010063

Chicago/Turabian Style

Rahaman, Md. M., Ahmed Rakib, Saikat Mitra, Abu M. Tareq, Talha B. Emran, A. F.M. Shahid-Ud-Daula, Mohammad N. Amin, and Jesus Simal-Gandara. 2021. "The Genus Curcuma and Inflammation: Overview of the Pharmacological Perspectives" Plants 10, no. 1: 63. https://doi.org/10.3390/plants10010063

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