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Article

Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space

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Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
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Canadian Light Source, University of Saskatchewan, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada
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Clinical Research Support Unit, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Sally A. Moody and Simon J. Conway
J. Dev. Biol. 2021, 9(1), 8; https://doi.org/10.3390/jdb9010008
Received: 3 December 2020 / Revised: 18 February 2021 / Accepted: 1 March 2021 / Published: 12 March 2021
(This article belongs to the Special Issue Craniofacial Genetics and Developmental Biology)
For humans and other mammals to eat effectively, teeth must develop properly inside the jaw. Deciphering craniodental integration is central to explaining the timely formation of permanent molars, including third molars which are often impacted in humans, and to clarifying how teeth and jaws fit, function and evolve together. A factor long-posited to influence molar onset time is the jaw space available for each molar organ to form within. Here, we tested whether each successive molar initiates only after a minimum threshold of space is created via jaw growth. We used synchrotron-based micro-CT scanning to assess developing molars in situ within jaws of C57BL/6J mice aged E10 to P32, encompassing molar onset to emergence. We compared total jaw, retromolar and molar lengths, and molar onset times, between upper and lower jaws. Initiation time and developmental duration were comparable between molar upper and lower counterparts despite shorter, slower-growing retromolar space in the upper jaw, and despite size differences between upper and lower molars. Timing of molar formation appears unmoved by jaw length including space. Conditions within the dental lamina likely influence molar onset much more than surrounding jaw tissues. We theorize that molar initiation is contingent on sufficient surface area for the physical reorganization of dental epithelium and its invagination of underlying mesenchyme. View Full-Text
Keywords: tooth development; molar initiation; craniodental integration; 3D imaging; synchrotron scanning tooth development; molar initiation; craniodental integration; 3D imaging; synchrotron scanning
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MDPI and ACS Style

Ko, D.; Kelly, T.; Thompson, L.; Uppal, J.K.; Rostampour, N.; Webb, M.A.; Zhu, N.; Belev, G.; Mondal, P.; Cooper, D.M.L.; Boughner, J.C. Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space. J. Dev. Biol. 2021, 9, 8. https://doi.org/10.3390/jdb9010008

AMA Style

Ko D, Kelly T, Thompson L, Uppal JK, Rostampour N, Webb MA, Zhu N, Belev G, Mondal P, Cooper DML, Boughner JC. Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space. Journal of Developmental Biology. 2021; 9(1):8. https://doi.org/10.3390/jdb9010008

Chicago/Turabian Style

Ko, Daisy, Tess Kelly, Lacey Thompson, Jasmene K. Uppal, Nasim Rostampour, Mark A. Webb, Ning Zhu, George Belev, Prosanta Mondal, David M.L. Cooper, and Julia C. Boughner 2021. "Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space" Journal of Developmental Biology 9, no. 1: 8. https://doi.org/10.3390/jdb9010008

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