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Review

Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development

1
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
2
Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
3
BioKansas, Shawnee, KS 66217, USA
*
Author to whom correspondence should be addressed.
Current address: Senior Technical Writer, Catalent Pharma Solutions, 726 Heartland Trail, Madison, WI 53717, USA.
Academic Editors: Brian Ackley and Simon J. Conway
J. Dev. Biol. 2021, 9(1), 11; https://doi.org/10.3390/jdb9010011
Received: 23 February 2021 / Revised: 15 March 2021 / Accepted: 17 March 2021 / Published: 21 March 2021
(This article belongs to the Special Issue Cell Adhesion Molecules in Development)
The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for organ function and endows the epidermis with a barrier function to restrict the passage of pathogens. Over the past twenty-five years, numerous investigators have identified more than 30 proteins that are required for the formation or maintenance of the SJs in Drosophila melanogaster, and have determined many of the steps involved in the biogenesis of the junction. Along the way, it has become clear that SJ proteins are also required for a number of developmental events that occur throughout the life of the organism. Many of these developmental events occur prior to the formation of the occluding junction, suggesting that SJ proteins possess non-occluding functions. In this review, we will describe the composition of SJs, taking note of which proteins are core components of the junction versus resident or accessory proteins, and the steps involved in the biogenesis of the junction. We will then elaborate on the functions that core SJ proteins likely play outside of their role in forming the occluding junction and describe studies that provide some cell biological perspectives that are beginning to provide mechanistic understanding of how these proteins function in developmental contexts. View Full-Text
Keywords: septate junction; epithelia; Drosophila; morphogenesis; apical/basal polarity; planar polarity; wound healing; dorsal closure; organogenesis; secretion septate junction; epithelia; Drosophila; morphogenesis; apical/basal polarity; planar polarity; wound healing; dorsal closure; organogenesis; secretion
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MDPI and ACS Style

Rice, C.; De, O.; Alhadyian, H.; Hall, S.; Ward, R.E. Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development. J. Dev. Biol. 2021, 9, 11. https://doi.org/10.3390/jdb9010011

AMA Style

Rice C, De O, Alhadyian H, Hall S, Ward RE. Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development. Journal of Developmental Biology. 2021; 9(1):11. https://doi.org/10.3390/jdb9010011

Chicago/Turabian Style

Rice, Clinton, Oindrila De, Haifa Alhadyian, Sonia Hall, and Robert E. Ward 2021. "Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development" Journal of Developmental Biology 9, no. 1: 11. https://doi.org/10.3390/jdb9010011

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