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C. elegans Apical Extracellular Matrices Shape Epithelia

Department of Genetics, University of Pennsylvania Perelman School of Medicine 415 Curie Blvd, Philadelphia, PA 19104-6145, USA
Author to whom correspondence should be addressed.
J. Dev. Biol. 2020, 8(4), 23;
Received: 4 July 2020 / Revised: 26 August 2020 / Accepted: 27 August 2020 / Published: 6 October 2020
(This article belongs to the Special Issue Caenorhabditis elegans - A Developmental Genetic Model System)
Apical extracellular matrices (aECMs) coat exposed surfaces of epithelia to shape developing tissues and protect them from environmental insults. Despite their widespread importance for human health, aECMs are poorly understood compared to basal and stromal ECMs. The nematode Caenorhabditis elegans contains a variety of distinct aECMs, some of which share many of the same types of components (lipids, lipoproteins, collagens, zona pellucida domain proteins, chondroitin glycosaminoglycans and proteoglycans) with mammalian aECMs. These aECMs include the eggshell, a glycocalyx-like pre-cuticle, both collagenous and chitin-based cuticles, and other understudied aECMs of internal epithelia. C. elegans allows rapid genetic manipulations and live imaging of fluorescently-tagged aECM components, and is therefore providing new insights into aECM structure, trafficking, assembly, and functions in tissue shaping. View Full-Text
Keywords: C. elegans; apical extracellular matrix; cuticle; eggshell; glycocalyx C. elegans; apical extracellular matrix; cuticle; eggshell; glycocalyx
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MDPI and ACS Style

Cohen, J.D.; Sundaram, M.V. C. elegans Apical Extracellular Matrices Shape Epithelia. J. Dev. Biol. 2020, 8, 23.

AMA Style

Cohen JD, Sundaram MV. C. elegans Apical Extracellular Matrices Shape Epithelia. Journal of Developmental Biology. 2020; 8(4):23.

Chicago/Turabian Style

Cohen, Jennifer D., and Meera V. Sundaram. 2020. "C. elegans Apical Extracellular Matrices Shape Epithelia" Journal of Developmental Biology 8, no. 4: 23.

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