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A Series of Tubes: The C. elegans Excretory Canal Cell as a Model for Tubule Development

1
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
2
Deciphera, Pharmaceuticals, Inc., Lawrence, KS 66044, USA
*
Author to whom correspondence should be addressed.
J. Dev. Biol. 2020, 8(3), 17; https://doi.org/10.3390/jdb8030017
Received: 12 August 2020 / Revised: 31 August 2020 / Accepted: 2 September 2020 / Published: 7 September 2020
(This article belongs to the Special Issue Caenorhabditis elegans - A Developmental Genetic Model System)
Formation and regulation of properly sized epithelial tubes is essential for multicellular life. The excretory canal cell of C. elegans provides a powerful model for investigating the integration of the cytoskeleton, intracellular transport, and organismal physiology to regulate the developmental processes of tube extension, lumen formation, and lumen diameter regulation in a narrow single cell. Multiple studies have provided new understanding of actin and intermediate filament cytoskeletal elements, vesicle transport, and the role of vacuolar ATPase in determining tube size. Most of the genes discovered have clear homologues in humans, with implications for understanding these processes in mammalian tissues such as Schwann cells, renal tubules, and brain vasculature. The results of several new genetic screens are described that provide a host of new targets for future studies in this informative structure. View Full-Text
Keywords: epithelial tube; apical surface; vesicle transport; exocytosis; vacuolar ATPase; intermediate filaments; terminal web; IRG protein epithelial tube; apical surface; vesicle transport; exocytosis; vacuolar ATPase; intermediate filaments; terminal web; IRG protein
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MDPI and ACS Style

Buechner, M.; Yang, Z.; Al-Hashimi, H. A Series of Tubes: The C. elegans Excretory Canal Cell as a Model for Tubule Development. J. Dev. Biol. 2020, 8, 17. https://doi.org/10.3390/jdb8030017

AMA Style

Buechner M, Yang Z, Al-Hashimi H. A Series of Tubes: The C. elegans Excretory Canal Cell as a Model for Tubule Development. Journal of Developmental Biology. 2020; 8(3):17. https://doi.org/10.3390/jdb8030017

Chicago/Turabian Style

Buechner, Matthew, Zhe Yang, and Hikmat Al-Hashimi. 2020. "A Series of Tubes: The C. elegans Excretory Canal Cell as a Model for Tubule Development" Journal of Developmental Biology 8, no. 3: 17. https://doi.org/10.3390/jdb8030017

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