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Review

Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone

Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J. Dev. Biol. 2020, 8(3), 14; https://doi.org/10.3390/jdb8030014
Received: 14 June 2020 / Revised: 13 July 2020 / Accepted: 15 July 2020 / Published: 22 July 2020
(This article belongs to the Special Issue Caenorhabditis elegans - A Developmental Genetic Model System)
The C. elegans germ line and its gonadal support cells are well studied from a developmental genetics standpoint and have revealed many foundational principles of stem cell niche biology. Among these are the observations that a niche-like cell supports a self-renewing stem cell population with multipotential, differentiating daughter cells. While genetic features that distinguish stem-like cells from their differentiating progeny have been defined, the mechanisms that structure these populations in the germ line have yet to be explained. The spatial restriction of Notch activation has emerged as an important genetic principle acting in the distal germ line. Synthesizing recent findings, I present a model in which the germ stem cell population of the C. elegans adult hermaphrodite can be recognized as two distinct anatomical and genetic populations. This review describes the recent progress that has been made in characterizing the undifferentiated germ cells and gonad anatomy, and presents open questions in the field and new directions for research to pursue. View Full-Text
Keywords: C. elegans; germ line; stem cell; progenitor cell; Notch C. elegans; germ line; stem cell; progenitor cell; Notch
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MDPI and ACS Style

Gordon, K. Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone. J. Dev. Biol. 2020, 8, 14. https://doi.org/10.3390/jdb8030014

AMA Style

Gordon K. Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone. Journal of Developmental Biology. 2020; 8(3):14. https://doi.org/10.3390/jdb8030014

Chicago/Turabian Style

Gordon, Kacy. 2020. "Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone" Journal of Developmental Biology 8, no. 3: 14. https://doi.org/10.3390/jdb8030014

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