Next Article in Journal
Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice
Previous Article in Journal / Special Issue
Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System
Open AccessReview

I Spy in the Developing Fly a Multitude of Ways to Die

1
Cell and Molecular Biology Program, Department of Biology, 5 Cummington Mall, Boston University, Boston, MA 02215, USA
2
Molecular Biology, Cell Biology, and Biochemistry Program, 5 Cummington Mall, Boston University, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Dev. Biol. 2018, 6(4), 26; https://doi.org/10.3390/jdb6040026
Received: 26 September 2018 / Revised: 18 October 2018 / Accepted: 19 October 2018 / Published: 22 October 2018
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
Cell proliferation and cell death are two opposing, yet complementary fundamental processes in development. Cell proliferation provides new cells, while developmental programmed cell death adjusts cell numbers and refines structures as an organism grows. Apoptosis is the best-characterized form of programmed cell death; however, there are many other non-apoptotic forms of cell death that occur throughout development. Drosophila is an excellent model for studying these varied forms of cell death given the array of cellular, molecular, and genetic techniques available. In this review, we discuss select examples of apoptotic and non-apoptotic cell death that occur in different tissues and at different stages of Drosophila development. For example, apoptosis occurs throughout the nervous system to achieve an appropriate number of neurons. Elsewhere in the fly, non-apoptotic modes of developmental cell death are employed, such as in the elimination of larval salivary glands and midgut during metamorphosis. These and other examples discussed here demonstrate the versatility of Drosophila as a model organism for elucidating the diverse modes of programmed cell death. View Full-Text
Keywords: programmed cell death; apoptosis; non-apoptotic cell death; autophagy; Drosophila; ovary; testis; salivary gland; midgut; neuroblast; glia programmed cell death; apoptosis; non-apoptotic cell death; autophagy; Drosophila; ovary; testis; salivary gland; midgut; neuroblast; glia
Show Figures

Figure 1

MDPI and ACS Style

Yalonetskaya, A.; Mondragon, A.A.; Elguero, J.; McCall, K. I Spy in the Developing Fly a Multitude of Ways to Die. J. Dev. Biol. 2018, 6, 26.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop