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Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System

Massachusetts General Hospital Cutaneous Biology Research Center, Harvard Medical School, Boston, MA 02129, USA
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J. Dev. Biol. 2018, 6(4), 25; https://doi.org/10.3390/jdb6040025
Received: 25 September 2018 / Revised: 16 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
Stem cells face a diversity of choices throughout their lives. At specific times, they may decide to initiate cell division, terminal differentiation, or apoptosis, or they may enter a quiescent non-proliferative state. Neural stem cells in the Drosophila central nervous system do all of these, at stereotypical times and anatomical positions during development. Distinct populations of neural stem cells offer a unique system to investigate the regulation of a particular stem cell behavior, while comparisons between populations can lead us to a broader understanding of stem cell identity. Drosophila is a well-described and genetically tractable model for studying fundamental stem cell behavior and the mechanisms that underlie cell-fate decisions. This review will focus on recent advances in our understanding of the factors that contribute to distinct stem cell-fate decisions within the context of the Drosophila nervous system. View Full-Text
Keywords: stem cell biology; neuroblast; cell cycle; apoptosis; Drosophila; development stem cell biology; neuroblast; cell cycle; apoptosis; Drosophila; development
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Harding, K.; White, K. Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System. J. Dev. Biol. 2018, 6, 25.

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