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J. Dev. Biol. 2018, 6(2), 8; https://doi.org/10.3390/jdb6020008

Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA
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Received: 30 January 2018 / Revised: 23 March 2018 / Accepted: 24 March 2018 / Published: 28 March 2018
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
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Abstract

In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology. View Full-Text
Keywords: Wnt/Wingless signaling; Drosophila gut; animal model; intestinal physiology and pathology; Adenomatous polyposis coli (APC); colorectal cancer Wnt/Wingless signaling; Drosophila gut; animal model; intestinal physiology and pathology; Adenomatous polyposis coli (APC); colorectal cancer
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Tian, A.; Benchabane, H.; Ahmed, Y. Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective. J. Dev. Biol. 2018, 6, 8.

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