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J. Dev. Biol. 2017, 5(4), 13; https://doi.org/10.3390/jdb5040013

Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control

Philipps University Marburg, Institute of Molecular Biology and Tumor Research (IMT), Center for Tumor and Immune Biology (ZTI), Hans-Meerwein-Str. 3, 35043 Marburg, Germany
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Received: 1 November 2017 / Revised: 17 November 2017 / Accepted: 18 November 2017 / Published: 21 November 2017
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
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Abstract

Hedgehog (Hh)/GLI signaling is an important instructive cue in various processes during embryonic development, such as tissue patterning, stem cell maintenance, and cell differentiation. It also plays crucial roles in the development of many pediatric and adult malignancies. Understanding the molecular mechanisms of pathway regulation is therefore of high interest. Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) comprise a group of protein kinases which are emerging modulators of signal transduction, cell proliferation, survival, and cell differentiation. Work from the last years has identified a close regulatory connection between DYRKs and the Hh signaling system. In this manuscript, we outline the mechanistic influence of DYRK kinases on Hh signaling with a focus on the mammalian situation. We furthermore aim to bring together what is known about the functional consequences of a DYRK-Hh cross-talk and how this might affect cellular processes in development, physiology, and pathology. View Full-Text
Keywords: hedgehog; GLI1; dual-specificity tyrosine-regulated kinase; DYRK; MIRK; Down syndrome hedgehog; GLI1; dual-specificity tyrosine-regulated kinase; DYRK; MIRK; Down syndrome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Singh, R.; Lauth, M. Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control. J. Dev. Biol. 2017, 5, 13.

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