Next Article in Journal / Special Issue
Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors
Previous Article in Journal / Special Issue
Control of Hedgehog Signalling by the Cilia-Regulated Proteasome
Article Menu

Export Article

Open AccessReview

Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage

Neuroprotective, Neuroregenerative and Remyelinating Small Molecules’ U1195, INSERM—Université Paris-Sud, Université Paris-Saclay, 80 rue du Général Leclerc, Kremlin-Bicêtre F-94276, France
IRCM, Molecular Biology of Neural Development, 110 Pine Avenue West, Montreal, QC H2W 1R7, Canada
Author to whom correspondence should be addressed.
Academic Editors: Henk Roelink and Simon J. Conway
J. Dev. Biol. 2016, 4(3), 28;
Received: 15 July 2016 / Revised: 26 August 2016 / Accepted: 31 August 2016 / Published: 8 September 2016
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
PDF [1124 KB, uploaded 8 September 2016]


The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central nervous system which after maturation are responsible for axon myelination. In accordance with the requirement for Hedgehog signaling in ventral patterning, the earliest identifiable cells in the oligodendrocyte lineage are derived from the ventral ventricular zone of the developing spinal cord and brain. Here, we present the current knowledge about the involvement of Hedgehog signaling in the strict spatial and temporal regulation which characterizes the initiation and progression of the oligodendrocyte lineage. We notably describe the ability of the Hedgehog signaling to tightly orchestrate the appearance of specific combinations of genes in concert with other pathways. We document the molecular mechanisms controlling Hedgehog temporal activity during OPC specification. The contribution of the pathway to aspects of OPC development different from their specification is also highlighted especially in the optic nerve. Finally, we report the data demonstrating that Hedgehog signaling-dependency is not a universal situation for oligodendrocyte generation as evidenced in the dorsal spinal cord in contrast to the dorsal forebrain. View Full-Text
Keywords: oligodendrocyte; neural tube; forebrain; optic nerve; Smoothened; Patched; Gli oligodendrocyte; neural tube; forebrain; optic nerve; Smoothened; Patched; Gli

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Traiffort, E.; Zakaria, M.; Laouarem, Y.; Ferent, J. Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage. J. Dev. Biol. 2016, 4, 28.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top