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Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors

1
Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA
2
College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea
3
Programs in Neuroscience and Developmental Biology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Henk Roelink
J. Dev. Biol. 2016, 4(4), 29; https://doi.org/10.3390/jdb4040029
Received: 14 June 2016 / Revised: 7 September 2016 / Accepted: 20 September 2016 / Published: 29 September 2016
(This article belongs to the Collection Hedgehog Signaling in Embryogenesis)
Neural progenitors in the embryonic neocortex must be tightly regulated in order to generate the correct number and projection neuron subtypes necessary for the formation of functional neocortical circuits. In this study, we show that the intracellular protein Suppressor of Fused (Sufu) regulates the proliferation of intermediate progenitor (IP) cells at later stages of corticogenesis to affect the number of Cux1+ upper layer neurons in the postnatal neocortex. This correlates with abnormal levels of the repressor form of Gli3 (Gli3R) and the ectopic expression of Patched 1 (Ptch1), a Sonic Hedgehog (Shh) target gene. These studies reveal that the canonical role of Sufu as an inhibitor of Shh signaling is conserved at later stages of corticogenesis and that Sufu plays a crucial role in regulating neuronal number by controlling the cell cycle dynamics of IP cells in the embryonic neocortex. View Full-Text
Keywords: Suppressor of Fused; Sonic Hedgehog; Gli3; corticogenesis; neurogenesis Suppressor of Fused; Sonic Hedgehog; Gli3; corticogenesis; neurogenesis
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Yabut, O.R.; Ng, H.X.; Fernandez, G.; Yoon, K.; Kuhn, J.; Pleasure, S.J. Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors. J. Dev. Biol. 2016, 4, 29.

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