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Article

The Shape of the Jaw—Zebrafish Col11a1a Regulates Meckel’s Cartilage Morphogenesis and Mineralization

Department of Biological Sciences, Biomolecular Research Center, Center of Biomedical Research Excellence in Matrix Biology, Boise State University, Boise, ID 83725, USA
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Academic Editors: Kristin Bruk Artinger and Simon J. Conway
J. Dev. Biol. 2022, 10(4), 40; https://doi.org/10.3390/jdb10040040
Received: 15 July 2022 / Revised: 19 August 2022 / Accepted: 14 September 2022 / Published: 22 September 2022
(This article belongs to the Special Issue 2022 Feature Papers by JDB’s Editorial Board Members)
The expression of the col11a1a gene is essential for normal skeletal development, affecting both cartilage and bone. Loss of function mutations have been shown to cause abnormalities in the growth plate of long bones, as well as in craniofacial development. However, the specific effects on Meckel’s cartilage have not been well studied. To further understand the effect of col11a1a gene function, we analyzed the developing jaw in zebrafish using gene knockdown by the injection of an antisense morpholino oligonucleotide using transgenic Tg(sp7:EGFP) and Tg(Fli1a:EGFP) EGFP reporter fish, as well as wildtype AB zebrafish. Our results demonstrate that zebrafish col11a1a knockdown impairs the cellular organization of Meckel’s cartilage in the developing jaw and alters the bone formation that occurs adjacent to the Meckel’s cartilage. These results suggest roles for Col11a1a protein in cartilage intermediates of bone development, the subsequent mineralization of the bony collar of long bones, and that which occurs adjacent to Meckel’s cartilage in the developing jaw. View Full-Text
Keywords: Meckel’s cartilage; jaw development; mineralization; craniofacial; zebrafish; Stickler syndrome type II; Marshall syndrome; fibrochondrogenesis Meckel’s cartilage; jaw development; mineralization; craniofacial; zebrafish; Stickler syndrome type II; Marshall syndrome; fibrochondrogenesis
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MDPI and ACS Style

Reeck, J.C.; Oxford, J.T. The Shape of the Jaw—Zebrafish Col11a1a Regulates Meckel’s Cartilage Morphogenesis and Mineralization. J. Dev. Biol. 2022, 10, 40. https://doi.org/10.3390/jdb10040040

AMA Style

Reeck JC, Oxford JT. The Shape of the Jaw—Zebrafish Col11a1a Regulates Meckel’s Cartilage Morphogenesis and Mineralization. Journal of Developmental Biology. 2022; 10(4):40. https://doi.org/10.3390/jdb10040040

Chicago/Turabian Style

Reeck, Jonathon C., and Julia Thom Oxford. 2022. "The Shape of the Jaw—Zebrafish Col11a1a Regulates Meckel’s Cartilage Morphogenesis and Mineralization" Journal of Developmental Biology 10, no. 4: 40. https://doi.org/10.3390/jdb10040040

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