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Open AccessArticle

Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug

1
Laboratory of Microscopic Imaging and Specialized Biological Techniques, Faculty of Biology and Environmental Protection, University of Lodz, Banacha12/16, 90-237 Lodz, Poland
2
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
3
Networking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), Monforte de Lemos 3-5, Pabellon´ 11, Planta, 028029 Madrid, Spain
4
Departamento Química Orgánica y Química Inorganica, Universidad de Alcalá, Instituto de Investigación Química “Andrés M. del Río” (IQAR), UAH, 28871 Alcalá de Henares, Spain
5
Institute of Biophysics and Cell Engineering of NASB, Akademicheskaja 27, 220072 Minsk, Belarus
6
Instituto Ramon y Cajal de Investigacion Sanitaria, IRYCIS, Colmenar Viejo Road, Km 9, 100, 28034 Madrid, Spain
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(9), 411; https://doi.org/10.3390/biom9090411
Received: 22 July 2019 / Revised: 20 August 2019 / Accepted: 21 August 2019 / Published: 25 August 2019
Metallodendrimers—dendrimers with included metals—are widely investigated as biocompatible equivalents to metal nanoparticles. Applications can be expected in the fields of catalysis, as chemical sensors in molecular recognition and as anticancer drugs. Metallodendrimers can also mimic certain biomolecules, for example, haemoprotein in the case of using a dendrimer with a porphyrin core. In previous papers, we showed the promising anticancer effects of carbosilane ruthenium dendrimers. The present paper is devoted to studying biocompatibility and the cytotoxic effect on normal and cancer cells of carbosilane ruthenium dendrimers labelled with fluorescent probe fluorescein isothiocyanate (FITC). The addition of fluorescent probe allowed tracking the metallodendrimer in both normal and cancer cells. It was found that carbosilane ruthenium dendrimer labelled with FITC in concentration up to 10 µmol/L was more cytotoxic for cancer cells than for normal cells. Thus, FITC labelled carbosilane ruthenium dendrimer is a good candidate for diagnostic imaging and studying anticancer effects of metallodendrimers in cancer therapy. View Full-Text
Keywords: ruthenium dendrimer; FITC labelled dendrimer; anticancer therapeutic agent; controlled polymer carrier ruthenium dendrimer; FITC labelled dendrimer; anticancer therapeutic agent; controlled polymer carrier
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Michlewska, S.; Kubczak, M.; Maroto-Díaz, M.; Sanz del Olmo, N.; Ortega, P.; Shcharbin, D.; Gomez Ramirez, R.; Javier de la Mata, F.; Ionov, M.; Bryszewska, M. Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug. Biomolecules 2019, 9, 411.

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