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Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease

Laboratory of Gene Therapy, Biocad Biotechnology Company, Saint-Petersburg, Strelnya 198515, Russia
Federal Scientific Clinical Center for Resuscitation and Rehabilitation, Moscow 109240, Russia
Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan
Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russia
Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 121609, Russia
Institute of Human Morphology, Moscow 117418, Russia
Institute of General Pathology and Pathophysiology, Moscow 125315, Russia
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(8), 377;
Received: 2 June 2019 / Revised: 8 August 2019 / Accepted: 13 August 2019 / Published: 18 August 2019
Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis. View Full-Text
Keywords: atherosclerosis; mitochondria; mtDNA; mutations; heteroplasmy; molecular markers atherosclerosis; mitochondria; mtDNA; mutations; heteroplasmy; molecular markers
MDPI and ACS Style

Volobueva, A.; Grechko, A.; Yet, S.-F.; Sobenin, I.; Orekhov, A. Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease. Biomolecules 2019, 9, 377.

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