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Biomolecules 2019, 9(3), 100;

Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment

Department of Biological Sciences, School of Science, University of Jordan, Amman 11942, Jordan
Department of Biology, Yarmouk University, Irbid 21163, Jordan
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
Department of Medical Science, Irbid Faculty, Al-Balqa Applied University, Irbid 21110, Jordan
Author to whom correspondence should be addressed.
Received: 20 January 2019 / Revised: 2 March 2019 / Accepted: 8 March 2019 / Published: 12 March 2019
PDF [1559 KB, uploaded 21 March 2019]


Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can happen after exposure to a traumatic event. Post-traumatic stress disorder is common among mental health disorders that include mood and anxiety disorders. Omega-3 fatty acids (OMGs) are essential for the maintenance of brain function and prevention of cognition dysfunctions. However, the possible effect of OMG on memory impairment induced by PTSD has not been studied. In here, such an effect was explored using a rat model of PTSD. The PTSD-like behavior was induced in animals using a single-prolonged stress (SPS) rat model of PTSD (2 h restraint, 20 min forced swimming, 15 min rest, 1–2 min diethyl ether exposure). The OMG was administered orally at a dose of 100 mg omega-3 polyunsaturated fatty acid (PUFA)/100 g body weight/day. Spatial learning and memory were assessed using the radial arm water maze (RAWM) method. Changes in oxidative stress biomarkers, thiobarbituric acid reactive substances (TBARS), and brain derived neuroptrophic factor (BDNF) in the hippocampus following treatments were measured. The results revealed that SPS impaired both short- and long-term memory (p < 0.05). Use of OMG prevented memory impairment induced by SPS. Furthermore, OMG normalized SPS induced changes in the hippocampus that reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratios, the activity of catalase, glutathione peroxidase (GPx), and TBARSs levels. In conclusion, the SPS model of PTSD-like behavior generated memory impairment, whereas OMG prevented this impairment, possibly through normalizing antioxidant mechanisms in the hippocampus. View Full-Text
Keywords: omega-3 fatty acids; post-traumatic traumatic stress; memory; single-prolonged stress; learning; oxidative stress; maze omega-3 fatty acids; post-traumatic traumatic stress; memory; single-prolonged stress; learning; oxidative stress; maze

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Alquraan, L.; Alzoubi, K.H.; Hammad, H.; Rababa’h, S.Y.; Mayyas, F. Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment. Biomolecules 2019, 9, 100.

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