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Biomolecules 2019, 9(2), 55; https://doi.org/10.3390/biom9020055

Phosphatases in Mitosis: Roles and Regulation

1,2,3
and
1,2,*
1
IBMC—Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal
2
i3S—Instituto de Investigação e Inovação em Saúde da Universidade do Porto, 4200-135 Porto, Portugal
3
Programa Doutoral em Biologia Molecular e Celular (MCbiology), Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
Received: 17 December 2018 / Revised: 31 January 2019 / Accepted: 1 February 2019 / Published: 7 February 2019
(This article belongs to the Special Issue Cytoskeleton and Regulation of Mitosis)
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Abstract

Mitosis requires extensive rearrangement of cellular architecture and of subcellular structures so that replicated chromosomes can bind correctly to spindle microtubules and segregate towards opposite poles. This process originates two new daughter nuclei with equal genetic content and relies on highly-dynamic and tightly regulated phosphorylation of numerous cell cycle proteins. A burst in protein phosphorylation orchestrated by several conserved kinases occurs as cells go into and progress through mitosis. The opposing dephosphorylation events are catalyzed by a small set of protein phosphatases, whose importance for the accuracy of mitosis is becoming increasingly appreciated. This review will focus on the established and emerging roles of mitotic phosphatases, describe their structural and biochemical properties, and discuss recent advances in understanding the regulation of phosphatase activity and function. View Full-Text
Keywords: mitosis; phosphatases; cell division cycle 25 (CDC25); protein phosphatase 1 (PP1); protein phosphatase 2A (PP2A); kinetochores; microtubules; chromosomes mitosis; phosphatases; cell division cycle 25 (CDC25); protein phosphatase 1 (PP1); protein phosphatase 2A (PP2A); kinetochores; microtubules; chromosomes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Moura, M.; Conde, C. Phosphatases in Mitosis: Roles and Regulation. Biomolecules 2019, 9, 55.

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