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Biomolecules 2018, 8(3), 69;

The Role of Calcium in Inflammation-Associated Bone Resorption

Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX 77555-0165, USA
Received: 28 June 2018 / Revised: 25 July 2018 / Accepted: 27 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Key Biomolecules in Bone Resorption)
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The aim of this mini-review is to discuss the role of calcium in the process of cytokine-mediated bone resorption in an effort to understand the role circulating calcium may play in the resorption of bone. The liberation of calcium and possibly phosphorus and magnesium by bone resorption may sustain and intensify the inflammatory response. We used a burn injury setting in humans and a burn injury model in animals in order to examine the effects on the bone of the systemic inflammatory response and identified the parathyroid calcium-sensing receptor as the mediator of increasing bone resorption, hence higher interleukin (IL)-1 production, and decreasing bone resorption, hence the lowering of circulating ionized calcium concentration. Thus, extracellular calcium, by means of the parathyroid calcium-sensing receptor, is able to modulate inflammation-mediated resorption. View Full-Text
Keywords: inflammation; bone resorption; calcium-sensing receptor; chemokines; NLRP3 inflammasome inflammation; bone resorption; calcium-sensing receptor; chemokines; NLRP3 inflammasome

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Klein, G.L. The Role of Calcium in Inflammation-Associated Bone Resorption. Biomolecules 2018, 8, 69.

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