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Biomolecules 2018, 8(3), 58;

Novel Approaches for BAV Aortopathy Prediction—Is There a Need for Cohort Studies and Biomarkers?

Department of Cardiovascular Surgery, University Heart Center, Martinistraße 52, 20246 Hamburg, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, 20246 Hamburg, Germany
Department of General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany
Author to whom correspondence should be addressed.
Received: 30 May 2018 / Revised: 9 July 2018 / Accepted: 13 July 2018 / Published: 19 July 2018
(This article belongs to the Special Issue Biomolecules for Translational Approaches in Cardiology)
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Bicuspid aortic valve (BAV) disease is the most common congenital malformation of the human heart with a prevalence of 1–2% in the general population. More than half of patients with a BAV present with a dilated proximal aorta (so-called bicuspid aortopathy) which is associated with an enhanced risk of life-threatening aortic complications. Up to now, the pathogenesis of bicuspid aortopathy as well as the risk stratification of aortic complications has not yet been sufficiently clarified. Recent findings have shown that bicuspid aortopathy features phenotypic heterogeneity. Two distinct valvulo-aortic phenotypes, the so-called root phenotype, as well as a dilation of the tubular ascending aorta, coincide with a significantly different risk for aortal complications. However, the phenotype-based classification that is only based on these two clinical forms is not sufficient to estimate the risk of aortal complications in a prognostically relevant way. Therefore, there is growing clinical interest to assess novel approaches in BAV research and to introduce circulating biomarkers as an elegant diagnostic tool to improve risk stratification in BAV aortopathy. A large scale epidemiological cohort study, ranking from apparently healthy individuals to disease patients, and comprehensive biobanks provide the opportunity to study BAV disease and its complications and to identify novel biomarkers for BAV aortopathy surveillance and prognosis. Firstly, the data indicate that several protein-based biomarkers and non-coding RNA molecules, in particular circulating microRNAs, can serve as relevant molecular biomarkers to predict the course of BAV-associated aortopathy. Here, we review the current literature and knowledge about BAV from a clinical point of view, and report about novel approaches in BAV biomarker research. View Full-Text
Keywords: bicuspid aortic valve; aortopathy; biomarkers; microRNAs bicuspid aortic valve; aortopathy; biomarkers; microRNAs

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Girdauskas, E.; Petersen, J.; Neumann, N.; Naito, S.; Gross, T.; Jagodzinski, A.; Reichenspurner, H.; Zeller, T. Novel Approaches for BAV Aortopathy Prediction—Is There a Need for Cohort Studies and Biomarkers? Biomolecules 2018, 8, 58.

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