Next Article in Journal
Evaluation of the Simultaneous Production of Xylitol and Ethanol from Sisal Fiber
Previous Article in Journal
Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview
Biomolecules 2018, 8(1), 1;

Emerging Roles for VEGF-D in Human Disease

Tumour Angiogenesis and Microenvironment Program, Peter MacCallum Cancer Centre, 305 Grattan St., Melbourne, VIC 3000, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia
Authors to whom correspondence should be addressed.
Received: 22 November 2017 / Revised: 22 December 2017 / Accepted: 28 December 2017 / Published: 4 January 2018
Full-Text   |   PDF [2771 KB, uploaded 4 January 2018]   |  


Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can promote the remodeling of blood vessels and lymphatics in development and disease. Recent fundamental and translational studies have provided insight into the molecular mechanisms by which VEGF-D exerts its effects in human disease. Hence this protein is now of interest as a therapeutic and/or diagnostic target, or as a potential therapeutic agent, in a diversity of indications in cardiovascular medicine, cancer and the devastating pulmonary condition lymphangioleiomyomatosis. This has led to clinical trial programs to assess the effect of targeting VEGF-D signaling pathways, or delivering VEGF-D, in angina, cancer and ocular indications. This review summarizes our understanding of VEGF-D signaling in human disease, which is largely based on animal disease models and clinicopathological studies, and provides information about the outcomes of recent clinical trials testing agonists or antagonists of VEGF-D signaling. View Full-Text
Keywords: VEGF-D; lymphatic vessels; endothelium; metastasis; growth factor; receptor; signaling; angiogenesis; lymphangiogenesis VEGF-D; lymphatic vessels; endothelium; metastasis; growth factor; receptor; signaling; angiogenesis; lymphangiogenesis

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Stacker, S.A.; Achen, M.G. Emerging Roles for VEGF-D in Human Disease. Biomolecules 2018, 8, 1.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top