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Biomolecules 2017, 7(3), 50;

TORC1-Dependent Phosphorylation Targets in Fission Yeast

Laboratory of Cell Responses, National Institute for Basic Biology, Nishigonaka 38, Myodaiji, Okazaki, Aichi 444-8585, Japan
Biosignal Research Center, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan
Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Nishigonaka 38, Myodaiji, Okazaki, Aichi 444-8585, Japan
Author to whom correspondence should be addressed.
Academic Editors: Kazuhiro Shiozaki and Ted Powers
Received: 2 June 2017 / Revised: 27 June 2017 / Accepted: 28 June 2017 / Published: 3 July 2017
(This article belongs to the Special Issue TOR Signaling Pathway)
Full-Text   |   PDF [1362 KB, uploaded 4 July 2017]   |  


Target of rapamycin (TOR) kinase controls cell metabolism and growth in response to environmental cues such as nutrients, growth factors, and stress. TOR kinase is widely conserved across eukaryotes. As in other organisms, the fission yeast Schizosaccharomyces pombe has two types of TOR complex, namely TOR complex 1 (TORC1) and TORC2. It is interesting that the two TOR complexes in S. pombe have opposite roles in sexual differentiation, which is induced by nutrient starvation. TORC1, which contains Tor2 as a catalytic subunit, promotes vegetative growth and represses sexual differentiation in nutrient-rich conditions, while TORC2 is required for the initiation of sexual differentiation. Multiple targets of TORC1 have been identified. Some of these, such as S6 kinase and an autophagy regulator Atg13, are known targets in other organisms. In addition, there is a novel group of TORC1 targets involved in the regulation of sexual differentiation. Here, we review recent findings on phosphorylation targets of TORC1 in S. pombe. Furthermore, we briefly report a novel S. pombe target of TORC1. View Full-Text
Keywords: TOR complex 1; fission yeast; sexual differentiation TOR complex 1; fission yeast; sexual differentiation

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Otsubo, Y.; Nakashima, A.; Yamamoto, M.; Yamashita, A. TORC1-Dependent Phosphorylation Targets in Fission Yeast. Biomolecules 2017, 7, 50.

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