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The Production Processes and Biological Effects of Intravenous Immunoglobulin

Department of Chemistry, Universidade de Évora, Colégio Luís António Verney, Rua Romão Ramalho 59, 7000-671 Évora, Portugal
Hematology Department, Champalimaud Center for the Unknown, Av. Brasília, 1400-038 Lisboa, Portugal
Author to whom correspondence should be addressed.
Academic Editor: Rhodri Ceredig
Biomolecules 2016, 6(1), 15;
Received: 23 August 2015 / Revised: 1 March 2016 / Accepted: 1 March 2016 / Published: 9 March 2016
(This article belongs to the Special Issue Immunoglobulin)
Immunoglobulin is a highly diverse autologous molecule able to influence immunity in different physiological and diseased situations. Its effect may be visible both in terms of development and function of B and T lymphocytes. Polyclonal immunoglobulin may be used as therapy in many diseases in different circumstances such as primary and secondary hypogammaglobulinemia, recurrent infections, polyneuropathies, cancer, after allogeneic transplantation in the presence of infections and/or GVHD. However, recent studies have broadened the possible uses of polyclonal immunoglobulin showing that it can stimulate certain sub-populations of T cells with effects on T cell proliferation, survival and function in situations of lymphopenia. These results present a novel and considerable impact of intravenous immunoglobulin (IVIg) treatment in situations of severe lymphopenia, a situation that can occur in cancer patients after chemo and radiotherapy treatments. In this review paper the established and experimental role of polyclonal immunoglobulin will be presented and discussed as well as the manufacturing processes involved in their production. View Full-Text
Keywords: IVIg; immunoglobulin; immune modulation; molecular mechanisms; IVIg production IVIg; immunoglobulin; immune modulation; molecular mechanisms; IVIg production
MDPI and ACS Style

Barahona Afonso, A.F.; João, C.M.P. The Production Processes and Biological Effects of Intravenous Immunoglobulin. Biomolecules 2016, 6, 15.

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