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Open AccessArticle

Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis

Department of Life Sciences and Biotechnology, University of Ferrara, Via L. Borsari 46, Ferrara 44121, Italy
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Academic Editor: Jürg Bähler
Biomolecules 2015, 5(3), 1979-1989; https://doi.org/10.3390/biom5031979
Received: 6 May 2015 / Revised: 31 July 2015 / Accepted: 3 August 2015 / Published: 19 August 2015
The yeast Candida tropicalis DSM 7524 produces xylitol, a natural, low-calorie sweetener, by fermentation of xylose. In order to increase xylitol production rate during the submerged fermentation process, some parameters-substrate (xylose) concentration, pH, aeration rate, temperature and fermentation strategy-have been optimized. The maximum xylitol yield reached at 60–80 g/L initial xylose concentration, pH 5.5 at 37 °C was 83.66% (w/w) on consumed xylose in microaerophilic conditions (kLa = 2·h−1). Scaling up on 3 L fermenter, with a fed-batch strategy, the best xylitol yield was 86.84% (w/w), against a 90% of theoretical yield. The hyper-acidophilic behaviour of C. tropicalis makes this strain particularly promising for industrial application, due to the possibility to work in non-sterile conditions. View Full-Text
Keywords: xylitol; xylose; fed batch fermentation; Candida tropicalis; hyper-acidophylic xylitol; xylose; fed batch fermentation; Candida tropicalis; hyper-acidophylic
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MDPI and ACS Style

Tamburini, E.; Costa, S.; Marchetti, M.G.; Pedrini, P. Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis. Biomolecules 2015, 5, 1979-1989.

AMA Style

Tamburini E, Costa S, Marchetti MG, Pedrini P. Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis. Biomolecules. 2015; 5(3):1979-1989.

Chicago/Turabian Style

Tamburini, Elena; Costa, Stefania; Marchetti, Maria G.; Pedrini, Paola. 2015. "Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis" Biomolecules 5, no. 3: 1979-1989.

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