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Transcription Blockage Leads to New Beginnings

1
Department of Radiation Oncology and Translational Oncology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA
2
Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-000, Brazil
3
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
4
Novartis Institutes of Biomedical Sciences, Cambridge, MA 02139, USA
5
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Biomolecules 2015, 5(3), 1600-1617; https://doi.org/10.3390/biom5031600
Received: 23 June 2015 / Revised: 9 July 2015 / Accepted: 16 July 2015 / Published: 21 July 2015
(This article belongs to the Special Issue DNA Damage Response)
Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes. View Full-Text
Keywords: DNA damage; DNA repair; RNA polymerase II; recovery of RNA synthesis DNA damage; DNA repair; RNA polymerase II; recovery of RNA synthesis
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MDPI and ACS Style

Andrade-Lima, L.C.; Veloso, A.; Ljungman, M. Transcription Blockage Leads to New Beginnings. Biomolecules 2015, 5, 1600-1617.

AMA Style

Andrade-Lima LC, Veloso A, Ljungman M. Transcription Blockage Leads to New Beginnings. Biomolecules. 2015; 5(3):1600-1617.

Chicago/Turabian Style

Andrade-Lima, Leonardo C.; Veloso, Artur; Ljungman, Mats. 2015. "Transcription Blockage Leads to New Beginnings" Biomolecules 5, no. 3: 1600-1617.

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