Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis
Abstract
:1. Introduction: Appropriate Inflammation and NF-κB Activity
2. Nuclear Receptor (NR) Modulation of NF-κB Signaling
3. NR4A Nuclear Receptors and NF-κB Signaling
4. NR4A Control of Acute Inflammation, Inflammatory Resolution and Tissue Repair
4.1. NR4A1 is Crucial for the Development of Ly6Clow Reparative Monocytes and Has an Anti-Inflammatory Effect in Monocyte/Macrophage Cells
4.2. Generation and Maintenance of Regulatory T Cells by NR4A Receptors
4.3. Role of NR4A Receptors in Maintaining Endothelial Cell Homeostasis
4.4. NR4A Receptors Mediate Growth Factor and Cytokine Responses in Mesenchymal Cells
5. Therapeutic Potential of Altering NR4A/NF-κB Interactions to Control Inflammation
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Murphy, E.P.; Crean, D. Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis. Biomolecules 2015, 5, 1302-1318. https://doi.org/10.3390/biom5031302
Murphy EP, Crean D. Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis. Biomolecules. 2015; 5(3):1302-1318. https://doi.org/10.3390/biom5031302
Chicago/Turabian StyleMurphy, Evelyn P., and Daniel Crean. 2015. "Molecular Interactions between NR4A Orphan Nuclear Receptors and NF-κB Are Required for Appropriate Inflammatory Responses and Immune Cell Homeostasis" Biomolecules 5, no. 3: 1302-1318. https://doi.org/10.3390/biom5031302