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Inhibitory Effect of b-AP15 on the 20S Proteasome

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
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Biomolecules 2014, 4(4), 931-939; https://doi.org/10.3390/biom4040931
Received: 5 June 2014 / Revised: 5 August 2014 / Accepted: 23 September 2014 / Published: 14 October 2014
(This article belongs to the Special Issue Proteasomes and Its Regulators)
The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles. View Full-Text
Keywords: proteasome inhibitor; b-AP15; 19S regulatory particles proteasome inhibitor; b-AP15; 19S regulatory particles
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MDPI and ACS Style

Huang, L.; Jung, K.; Chen, C.H. Inhibitory Effect of b-AP15 on the 20S Proteasome. Biomolecules 2014, 4, 931-939. https://doi.org/10.3390/biom4040931

AMA Style

Huang L, Jung K, Chen CH. Inhibitory Effect of b-AP15 on the 20S Proteasome. Biomolecules. 2014; 4(4):931-939. https://doi.org/10.3390/biom4040931

Chicago/Turabian Style

Huang, Li, Katherine Jung, and Chin H. Chen. 2014. "Inhibitory Effect of b-AP15 on the 20S Proteasome" Biomolecules 4, no. 4: 931-939. https://doi.org/10.3390/biom4040931

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