Next Article in Journal / Special Issue
Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
Previous Article in Journal
Variation in the Subcellular Localization and Protein Folding Activity among Arabidopsis thaliana Homologs of Protein Disulfide Isomerase
Previous Article in Special Issue
Biocatalysis for Biobased Chemicals
Article Menu

Export Article

Open AccessReview
Biomolecules 2013, 3(4), 870-888;

Biotechnological Applications of Transglutaminases

Chimie, Université de Montréal, 2900 Boulevard Edouard-Montpetit, Montréal, Québec, H3T 1J4, Canada
CGCC, the Center in Green Chemistry and Catalysis, Montréal, H3A 0B8, Canada
PROTEO, the Québec Network for Protein Function, Structure and Engineering, Québec, G1V 0A6, Canada
Biochimie, Université de Montréal, 2900 Boulevard Edouard-Montpetit, Montréal, Québec, H3T 1J4, Canada
Author to whom correspondence should be addressed.
Received: 12 September 2013 / Revised: 10 October 2013 / Accepted: 11 October 2013 / Published: 22 October 2013
(This article belongs to the Special Issue Enzymes and Their Biotechnological Applications)
Full-Text   |   PDF [764 KB, uploaded 22 October 2013]   |  


In nature, transglutaminases catalyze the formation of amide bonds between proteins to form insoluble protein aggregates. This specific function has long been exploited in the food and textile industries as a protein cross-linking agent to alter the texture of meat, wool, and leather. In recent years, biotechnological applications of transglutaminases have come to light in areas ranging from material sciences to medicine. There has also been a substantial effort to further investigate the fundamentals of transglutaminases, as many of their characteristics that remain poorly understood. Those studies also work towards the goal of developing transglutaminases as more efficient catalysts. Progress in this area includes structural information and novel chemical and biological assays. Here, we review recent achievements in this area in order to illustrate the versatility of transglutaminases. View Full-Text
Keywords: biocatalysis; transglutaminase; protein modification; protein labeling biocatalysis; transglutaminase; protein modification; protein labeling

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Rachel, N.M.; Pelletier, J.N. Biotechnological Applications of Transglutaminases. Biomolecules 2013, 3, 870-888.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top