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Sumoylation at the Host-Pathogen Interface

Department of Microbial & Molecular Pathogenesis, College of Medicine, Texas A & M Health Science Center, 8447 HWY 47, Bryan, TX 77807-1359, USA
Biomolecules 2012, 2(2), 203-227;
Received: 21 February 2012 / Revised: 21 March 2012 / Accepted: 27 March 2012 / Published: 5 April 2012
(This article belongs to the Special Issue Protein SUMOylation)
Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity. In addition to using sumoylation to regulate their own proteins, several viral pathogens have been shown to modulate overall host sumoylation levels. Given the large number of cellular targets for SUMO addition and the breadth of critical cellular processes that are regulated via sumoylation, viral modulation of overall sumoylation presumably alters the cellular environment to ensure that it is favorable for viral reproduction and/or persistence. Like some viruses, certain bacterial plant pathogens also target the sumoylation system, usually decreasing sumoylation to disrupt host anti-pathogen responses. The recent demonstration that Listeria monocytogenes also disrupts host sumoylation, and that this is required for efficient infection, extends the plant pathogen observations to a human pathogen and suggests that pathogen modulation of host sumoylation may be more widespread than previously appreciated. This review will focus on recent aspects of how pathogens modulate the host sumoylation system and how this benefits the pathogen. View Full-Text
Keywords: virus; bacteria; SUMO; SIMs; immunity virus; bacteria; SUMO; SIMs; immunity
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Wilson, V.G. Sumoylation at the Host-Pathogen Interface. Biomolecules 2012, 2, 203-227.

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